Reference

Intestinal absorption of zinc sulfate or zinc dipicolinate in patients with cirrhosis

Intestinal absorption of zinc sulfate or zinc dipicolinate in patients with cirrhosis.Some chemicals with cas registry numbers like 7733-02-0 and 17949-65-4 are also used. Abe, Hirohiko (Sch. Med., Kurume Univ., Kurume, Japan). Biomed. Res. Trace Elem., 2(2), 193-4 (Japanese) 1991. CODEN: BRTEE5. ISSN: 0916-717X. DOCUMENT TYPE: Journal CA Section: 14 (Mammalian Pathological Biochemistry) Section cross-reference(s): 1 In 21 patients with cirrhosis impaired handling of orally administered zinc sulfate was studied. Long-term administration of zinc sulfate failed to elevate the serum and red blood cell zinc concn. in 10 patients with cirrhosis. Two zinc tolerance tests were performed on another 11 patients with cirrhosis, one test using zinc sulfate and other using zinc dipicolinate. The administration of zinc sulfate showed the mild elevation of serum zinc level and small increase of urinary zinc level. Elevated serum and urinary zinc levels were seen 120 and 180 min after the administration of zinc dipicolinate, compared with zinc sulfate. This study shows impaired handling of orally administered zinc sulfate but not zinc dipicolinate in patients with cirrhosis. .