Detail of "17954-98-2"

Reference

Effect of leukotriene B4 (LTB4) on purified rat Leydig cell steroidogenesis

Effect of leukotriene B4 (LTB4) on purified rat Leydig cell steroidogenesis.Some chemicals with cas registry numbers like 9002-67-9 and 362-74-3 are also used. Papadopoulos, Vassilios; Drosdowsky, Michel; Carreau, Serge (Lab. Biochim., CHU Cote de Nacre, Caen 14033, Fr.). Int. Congr. Ser. - Excerpta Med., 716(Mol. Cell. Endocrinol. Testis), 261-4 (English) 1986. CODEN: EXMDA4. ISSN: 0531-5131. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) In purified rat Leydig cells, LTB4 [71160-24-2] (100 pg/mL) enhanced the stimulation of testosterone [58-22-0] prodn. induced by LH [9002-67-9] (1 mg/mL) or dibutyryl cAMP [362-74-3] (1 mM) by 200 and 54%, resp. LTB4 did not increase 22R-hydroxycholesterol [17954-98-2] (30 mM)-stimulated testosterone formation. LTB4 alone did not increase testosterone prodn. The site of LTB4 action in LH-dependent steroidogenesis is apparently localized between cAMP formation and the testosterone conversion from 22R-hydroxycholesterol. .

Stimulation of cholesterol side-chain cleavage by a luteinizing hormone-releasing hormone (luliberin) agonist (ICI 118630) in rat Leydig cells

Stimulation of cholesterol side-chain cleavage by a luteinizing hormone-releasing hormone (luliberin) agonist (ICI 118630) in rat Leydig cells. Sullivan, Mark H. F.; Cooke, Brian A. (Dep. Biochem. Chem., Univ. London, London NW3 2PF, UK). 2140-46-7 and 7440-70-2 are cas registry numbers. These chemicals are also mentioned in this article. Biochem. J., 216(3), 747-52 (English) 1983. CODEN: BIJOAK. ISSN: 0306-3275. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The action of a luliberin agonist (ICI 118630 [65807-02-5]) and lutropin [9002-67-9] on the activity of the cytochrome P 450 cholesterol side-chain cleavage enzyme [37292-81-2] in rat Leydig cells was investigated. This was carried out by studying the metab. of exogenous (22R)-22- [17954-98-2] and 25-hydroxycholesterol [2140-46-7] to testosterone [58-22-0]. Both hydroxycholesterols increased testosterone prodn. to higher levels than achieved by lutropin alone. Addn. of luliberin agonist but not lutropin increased further the metab. of the hydroxycholesterol to testosterone; this occurred in the presence of satg. and subsaturating levels of the hydroxycholesterols. This effect of luliberin agonist was potentiated in the presence of lutropin. The protein synthesis inhibitor, cycloheximide, inhibited the luliberin agonist-induced stimulation of the hydroxycholesterol metab. At low Ca levels (1.1 mM), testosterone prodn. was increased by addn. of (22R)-22-hydroxycholesterol but the luliberin agonist effect was negated. The calmodulin inhibitor trifluoperazine, inhibited (22R)-22-hydroxycholesterol-stimulated steroidogenesis and negated the luliberin agonist effect. Apparently, luliberin agonist specifically increases the synthesis of the cytochrome P 450 cholesterol side-chain cleavage enzyme in rat testis Leydig cells. .