Detail of "18017-73-7"

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Induction of histone acetylation and inhibition of growth by phenyl alkanoic acids and structurally related molecules

Induction of histone acetylation and inhibition of growth by phenyl alkanoic acids and structurally related molecules. Lea, Michael A.; Shareef, Asif; Sura, Monali; desBordes, Charles ( Department of Biochemistry and Molecular Biology, UMDNJ-New Jersey Medical School, Newark, NJ 07103, USA). Cancer Chemotherapy and Pharmacology, 54(1), 57-63 (English) 2004 Springer-Verlag. CODEN: CCPHDZ. ISSN: 0344-5704. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Purpose. 18017-73-7 are also occured in this study. A structure-activity study was undertaken to det. the influence of side chain length of Ph alkanoic acids and the degree of unsatn. of Ph alkenoic acids on the induction of histone acetylation and inhibition of cancer cell proliferation. Materials and methods. Studies on cell proliferation were performed with DS19 mouse erythroleukemic cells, PC-3 human prostate cancer cells and Caco-2 human colon cancer cells. Actions on histone deacetylase and the induction of histone acetylation were compared for 4-phenylbutyrate and structurally related mols. Results. Increasing inhibition of cell proliferation by Ph alkanoic acids together with a decrease in cells in S phase and an increase in apoptotic cells was obsd. with increased chain length between four and ten carbons. Introduction of double bonds into the side chain was assocd. with increased growth inhibition. In contrast, 4-phenylbutyrate was a more potent inhibitor of histone deacetylase and inducer of histone acetylation than the other Ph alkanoic acids examd. Conclusions. In comparison with the action of 4-phenylbutyrate, actions other than inhibition of histone deacetylase appear to be more important for growth inhibition by longer chain Ph alkanoic and Ph alkenoic acids. .