Detail of "18053-31-1"

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Anticonvulsant actions of fominoben: possible involvement of benzodiazepine receptors

Anticonvulsant actions of fominoben: possible involvement of benzodiazepine receptors. Baldino, Frank, Jr.; Krespan, Barbara; Geller, Herbert M. (Cent. Res. Dev. Dep., E. I. du Pont de Nemours and Co., Glenolden, PA 19036, USA). Pharmacol., Biochem. Behav., 21(1), 137-43 (English) 1984. CODEN: PBBHAU. ISSN: 0091-3057. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The benzodiazepine-like activity of fominoben (I) [18053-31-1], a compd. with prominent antitussive and respiratory stimulant actions, was studied by examg. the anticonvulsant actions of fominoben as well as its ability to displace benzodiazepine (BDZ) binding from brain membranes. Binding data demonstrated that fominoben displaced [3H]flunitrazepam binding from rat cortical membrane prepns. Furthermore when tested against [3H]ethyl-b-carboline-3-carboxylate, the addn. of GABA resulted in a mean shift of the IC50 from 4.05 mM to 2.2 mM, a characteristic of benzodiazepine agonists. Fominoben (50 and 100 mg/kg) completely protected mice from seizures induced by 50 mg/kg pentylenetetrazole (PTZ) and elevated the seizure latency against 75 mg/kg of PTZ. The anticonvulsant effects of fominoben were less pronounced against 3-mercaptopropionic acid-induced seizures. The benzodiazepine antagonist Ro 15-1788 antagonized the anticonvulsant action of fominoben against both convulsants. Taken together, these data suggest that the anticonvulsant action of fominoben may be mediated by agonistic actions at benzodiazepine binding sites.

Anxiolytic-like properties of fominoben

Anxiolytic-like properties of fominoben. Crawley, Jacqueline N.; Blumstein, Lisa K.; Baldino, Frank, Jr. (Cent. Res. Dev. Dep., E.Several reagents such as 18053-31-1 is used here. I. DuPont de Nemours and Co., Glenolden, PA 19036, USA). Eur. J. Pharmacol., 97(3-4), 277-81 (English) 1984. CODEN: EJPHAZ. ISSN: 0014-2999. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Fominoben (I) [18053-31-1] produced an antianxiety effects analogous to diazepam in a mouse exploratory model for anxiolytics. This action of fominoben was blocked by Ro15-1788, a benzodiazepine receptor antagonist, implicating a brain benzodiazepine binding site in this anxiolytic action of fominoben. .