Detail of "1808-12-4"

CAS Number:
1808-12-4
Name:
Ethanamine,2-[(4-bromophenyl)phenylmethoxy]-N,N-dimethyl-, hydrochloride (1:1)
Molecular Structure:
Formula:
C17H20 Br N O . Cl H
Molecular Weight:
370.75
Synonyms:
Ethanamine,2-[(4-bromophenyl)phenylmethoxy]-N,N-dimethyl-, hydrochloride (9CI);Ethylamine, 2-[(p-bromo-a-phenylbenzyl)oxy]-N,N-dimethyl-, hydrochloride (6CI,7CI,8CI);2-(4-Bromodiphenylmethoxy)ethyldimethylamine hydrochloride; 4-Bromo-a-phenylbenzyl2-dimethylaminoethyl ether hydrochloride; Ambodryl hydrochloride; Bromazinehydrochloride; Bromdiphenhydramine hydrochloride; Bromdiphenylhydraminehydrochloride; Bromodiphenhydramine hydrochloride; NSC 36113; b-(p-Bromobenzhydryloxy)ethyldimethylaminehydrochloride
Safety:
Poison by intravenous route. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of Br⁻, NO_x, and HCl. Details

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Self-association of diphenylmethane antihistaminics in aqueous solutions: Self-association of diphenylmethane antihistaminics in aqueous solutions. Okada, Toshichika (Natl. Inst. Hyg. Sci., Osaka, Japan). Iyakuhin Kenkyu, 7(3), 411-23 (Japanese) 1976. CODEN: IYKEDH. DOCUMENT TYPE: Journal; General Review CA Section: 63 (Pharmaceuticals) A review and discussion with 47 refs. on the self-assocn. of diphenhydramine-HCl [147-24-0], bromodiphenhydramine-HCl [1808-12-4], chlorcyclizine-HCl [14362-31-3] and diphenylpyraline-HCl [132-18-3] in aq. solns. in relation to their phys. and micellar properties.

Antibacterial activity of ambodryl and benadryl: Antibacterial activity of ambodryl and benadryl. Dastidar, Sujata G.; Saha, P. K.In this study， 58-33-3 and 14362-31-3 are also used.; Sanyamat, B.; Chakrabarty, A. N. (Div. Microbiol., Jadavpur Univ., Calcutta, India). J. Appl. Bacteriol., 41(2), 209-14 (English) 1976. CODEN: JABAA4. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Section cross-reference(s): 1 Ambodryl (I) [1808-12-4] and Benadryl (II) [147-24-0] at 50-100 .mu.g/ml inhibited a large no. of gram-neg. and gram-pos. bacteria in vitro, with I having a broader spectrum. Single i.p. doses (1.5 or 3 .mu.g/g body wt.) of the compds. protected mice from challenges with LD50 amts. of a virulent strain of Salmonella typhimurium. Multiplication of this organism in the liver, spleen, and blood was also inhibited by I and II. Other antihistamines tested exerted lesser antibacterial effects in vitro. .