Detail of "181695-72-7"

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Valdecoxib for Postoperative Pain Management After Cesarean Delivery: A Randomized, Double-Blind, Placebo-Controlled Study

All Rights Reserved. Valdecoxib for Postoperative Pain Management After Cesarean Delivery: A Randomized, Double-Blind, Placebo-Controlled Study. Carvalho, Brendan; Chu, Larry; Fuller, Andrea; Cohen, Sheila E.; Riley, Edward T. (Department of Anesthesia, Stanford University School of Medicine Stanford, Stanford, CA, USA). Anesthesia & Analgesia (Hagerstown, MD, United States), 103(3), 664-670 (English) 2006 Lippincott Williams & Wilkins. CODEN: AACRAT. ISSN: 0003-2999. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Although nonsteroidal antiinflammatory drugs (NSAIDs) improve postoperative pain relief after cesarean delivery, they carry potential side effects (e.g., bleeding). Perioperative cyclooxygenase (COX)-2 inhibitors show similar analgesic efficacy to nonsteroidal antiinflammatory drugs in many surgical models but have not been studied after cesarean delivery. We designed this randomized double-blind study to det. the analgesic efficacy and opioid-sparing effects of valdecoxib after cesarean delivery. Healthy patients undergoing elective cesarean delivery under spinal anesthesia were randomized to receive oral valdecoxib 20 mg or placebo every 12 h for 72 h postoperatively. As a result of cyclooxygenase-2 inhibitors safety concerns that became apparent during this study, the study was terminated early after evaluating 48 patients. We found no differences in total analgesic consumption between the valdecoxib and placebo groups (121 ± 70 vs. 143 ± 77 morphine mg-equiv., resp.; P = 0.26). Pain at rest and during activity were similar between the groups despite adequate post hoc power to have detected a clin. 181695-72-7 which is the cas registry number of one of substances is just one of reagents here. significant difference. There were also no differences in IV morphine requirements, time to first analgesic request, patient satisfaction, side effects, breast-feeding success, or functional activity. Postoperative pain was generally well controlled. Adding valdecoxib after cesarean delivery under spinal anesthesia with intrathecal morphine is not supported at this time. .

Solubility of Valdecoxib in the Presence of Poly(ethylene glycol) 4000, Poly(ethylene glycol) 6000, Poly(ethylene glycol) 8000, and Poly(ethylene glycol) 10 000 at (298

Solubility of Valdecoxib in the Presence of Poly(ethylene glycol) 4000, Poly(ethylene glycol) 6000, Poly(ethylene glycol) 8000, and Poly(ethylene glycol) 10 000 at (298.Some chemicals with cas registry numbers like 181695-72-7 and 25322-68-3 are also used.15, 303.15, and 308.15) K. Liu, Chenguang; Desai, Kashappa Goud H.; Liu, Chengsheng (Life Science College, Ocean University of China, Qingdao 266003, Peop. Rep. China). Journal of Chemical and Engineering Data, 50(1), 278-282 (English) 2005 American Chemical Society. CODEN: JCEAAX. ISSN: 0021-9568. DOCUMENT TYPE: Journal CA Section: 68 (Phase Equilibriums, Chemical Equilibriums, and Solutions) Section cross-reference(s): 47, 63, 69 The present study investigated the solubilization of valdecoxib in aq. soln. using poly(ethylene glycol) 4000, poly(ethylene glycol) 6000, poly(ethylene glycol) 8000, and poly(ethylene glycol) 10 000 at (298.15, 303.15, and 308.15) K. The anal. of valdecoxib is carried out by UV spectral measurements at lmax = 202 nm. The aq. soly. of valdecoxib could be enhanced by the addn. of an increasing mass fraction of all of the poly(ethylene glycols) tested as well as by increasing the temp. of the dissoln. media. The mol. wt. of the poly(ethylene glycols) tested played an important role in valdecoxib solubilization in the aq. medium. Among the poly(ethylene glycols) studied, poly(ethylene glycol) 4000 exhibited a higher solubilization potential than the others. Calcd. Gibbs free energy values were all neg. for all of the poly(ethylene glycol) + water mixts. at (298.15, 303.15, and 308.15) K, indicating the spontaneous nature of valdecoxib solubilization. In the case of PEG 4000 + water mixts., the DtrG° values decreased to a greater extent than those for the other carriers, namely PEG 6000, 8000, and 10 000. Consequently, the reaction conditions were more favorable in PEG 4000 + water mixts. than in other carrier + water mixts. .