Detail of "18279-21-5"

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Toxicity of organotin compounds

Toxicity of organotin compounds. II. Comparative in vivo and in vitro studies with various organotin and organolead compounds in different animal species with special emphasis on lymphocyte cytotoxicity. Seinen, Willem; Vos, Joseph G.; Van Spanje, Ine; Snoek, Margriet; Brands, Ruud; Hooykaas, Herbert (Fac. Vet. Sci., Univ. Utrecht, Utrecht, Neth.). Toxicol. Appl. Pharmacol., 42(1), 197-212 (English) 1977. CODEN: TXAPA9. ISSN: 0041-008X. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) A series of organotin and organolead compds. were fed to male and female weanling rats for 2 wk at dietary levels of 0, 50, or 150 ppm, in order to evaluate their toxic effects, with special emphasis on the thymus and peripheral lymphoid organs. A dose-related redn. in the wt. of thymus, spleen, and popliteal lymph node, assocd. with lymphocyte depletion in the cortex of the thymus and the thymus-dependent areas in the peripheral lymphoid organs, was obsd. in animals fed di-n-octyltin dichloride (DOTC) [3542-36-7] and di-n-butyltin dichloride (DBTC) [683-18-1]. As shown previously, these effects were not related to stress. Similar, but less pronounced, lymphoid organ changes occurred in animals fed diets contg. diethyltin dichloride (DETC) [866-55-7] and di-n-propyltin dichloride [867-36-7]. In contrast, other dialkyltin compds. (dimethyltin dichloride [753-73-1]; di-n-dodecyltin dibromide [65264-08-6]; and di-n-octadecyltin dibromide [65264-09-7]), as well as mono-n-octyltin trichloride (MOTC) [3091-25-6], tri-n-octyltin chloride [2587-76-0], and tetraoctyltin [3590-84-9] did not cause atrophy of lymphoid organs. Of the dialkyllead compds. tested, di-n-butyllead diacetate [2587-84-0] and di-n-hexyllead diacetate [18279-21-5], the latter caused distinct lymphoid atrophy, but only when assocd. with severe growth retardation. A similar structure-activity relation regarding thymus atrophy by dialkyltin compds. was obsd. after i.v. application. DOTC and DBTC were effective at a dose of 1 mg/kg. A dose-related decrease of thymus wt., cell count, and cell viability occurred in rats after a single i.v. injection of 0, 1, 2, 4, or 8 mg of DOTC/kg. The effect of DOTC was completely reversible. In contrast to rats, lymphoid atrophy did not occur in mice, guinea pigs, or Japanese quail fed DOTC or DBTC. In vitro incubation of thymocytes and bone marrow cells with DBTC and DOTC revealed the same selectivity regarding cell type and species origin of cells as was found in vivo. A dose-related decrease in the survival of rat thymocytes was obsd., whereas rat bone marrow cells were not affected by DBTC and DOTC at levels up to 50 mg/mL. In contrast, the no. and viability of mouse and guinea pig thymocytes exposed to DBTC were the same as the controls. As the survival of human thymocytes was markedly decreased by DBTC, it possibly acts in the same manner in man and rat. In agreement with in vivo results, the survival of rat thymocytes was not significantly decreased by dimethyltin dichloride and diethyltin dichloride.