Detail of "18296-44-1"

Reference

Study of presence of valepotriates in Valeriana preparations

Study of presence of valepotriates in Valeriana preparations. Van Meer, J. H.; Vand der Sluis, W. G.; Labadie, R. P. (Vakgroep Farmacogn. Utrecht, Farm. Lab., Utrecht, Neth.). Pharm. Weekbl., 112(1), 20-7 (Dutch) 1977. CODEN: PHWEAW. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The main valepotriate components of roots and stems of V. officinalis in the Netherlands were generally valtrate (I) [18296-44-1] and isovaleroxyhydroxydidrovaltrate [28325-56-6]. Didrovaltrate [18296-45-2] and acevaltrate [25161-41-5] were absent or present in small amts. along with other unidentified valepotriates. Most com. 25161-41-5 and 18296-45-2 which are cas registry numbers of chemicals are mentioned. prepns. from valerian root contained only trace amts. of valepotriates or none at all. The com. prepn. Valmane contained didrovaltrate, less amts. of I, and no acevaltrate. .

Effect of valepotriates on locomotor activity of mice

Effect of valepotriates on locomotor activity of mice. Hoelzl, J.; Fink, C. (Inst. Pharm. Biol., Philipps-Univ., Marburg/Lahn 3550, Fed. Rep. Ger.). Arzneim.-Forsch., 34(1), 44-7 (German) 1984. CODEN: ARZNAD. ISSN: 0004-4172. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Valtrate (I) [18296-44-1] inhibited spontaneous activity in mice at doses of 0.1 mg/kg, i.v., or 0.5 mg/kg, orally. An increase in the I dose to 4 mg/kg, i.v., did not produce a cataleptic effect but prolonged the duration of the inhibitory effect. Acetoxyvaltrate hydrin (II) [58523-22-1], an epoxide-free valepotriate deriv., also inhibited spontaneous activity in these animals, but at higher concns. only (4 mg/kg). Thus, the epoxide group of valepotriates is not essential for their central depressant effect. Since both I and II had a depressant effect on spontaneous activity, their therapeutic value should be further examd.