Detail of "1846-76-0"

Reference

p-Stacking Interactions and C-H×××X (X = O, Aryl) Hydrogen Bonding as Directing Features of the Supramolecular Self-Association in 3-Carboxy and 3-Amido Coumarin Derivatives

p-Stacking Interactions and C-H×××X (X = O, Aryl) Hydrogen Bonding as Directing Features of the Supramolecular Self-Association in 3-Carboxy and 3-Amido Coumarin Derivatives. Garcia-Baez, Efren V.; Martinez-Martinez, Francisco J.; Hoepfl, Herbert; Padilla-Martinez, Itzia I. (Departamento de Quimica, Unidad Profesional Interdisciplinaria de Biotecnologia del IPN, Mexico City 07340, Mex.). Crystal Growth & Design, 3(1), 35-45 (English) 2003 American Chemical Society. CODEN: CGDEFU. ISSN: 1528-7483. DOCUMENT TYPE: Journal CA Section: 22 (Physical Organic Chemistry) Section cross-reference(s): 75 The crystallog. study of 3-carboxy coumarins (I; R = OEt, NH2CH2Ph, NHCHMePh, piperidinyl) and 3-amido coumarins [II; R = Me, CO2Et (III)] is reported in the context of crystal engineering. The former compds. are described as two fused rings with opposed polarity, which are assocd. through parallel displaced p-stacking interactions.In this study，1846-90-8 is also used. The benzenoid ring B and the lactone ring L of one mol. interact with the lactone ring L' and benzenoid ring B' of the partner mol. with mean interplanar and mean intercentroid distances ranging between 3.385(6) and 3.67(2) ? and 3.679(1) and 4.081(3) ?, resp. 779-30-6 and 1846-76-0 which are cas registry numbers of chemicals are mentioned. Among the six possible arrangements between two pairwise overlapping coumarin mols., the anti tail-to-tail orientation was the most frequently obsd. Pairing through p-stacking interactions is less favored when changing the 3-carboxy for a 3-amido group or even annulled, as in 3-oxalamate III, because of the increasing H-bonding capability of the 3-amido group. The fused polar rings of coumarins I-III can also assoc. through p-stacking interactions in the presence of weak interactions such as C-H×××X (X = O or arom. ring), as long as these assocns. do not slip the mol. planes too far so that subsequent p-stacking interactions are avoided. ..

Facilitation of retinal function recovery by coumarin derivatives

Facilitation of retinal function recovery by coumarin derivatives. Liu, Shirley X. L.; Kapingu, M. C.; Wang, Ming-Shi; Chiou, George C. Y. (Inst. Ocular Pharmacology and Dep. Med. Pharmacology and Toxicology, Texas A&M Univ. Coll. Med., College Station, TX, USA). Journal of Ocular Pharmacology and Therapeutics, 13(1), 69-79 (English) 1997 Liebert. CODEN: JOPTFU. ISSN: 1080-7683. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Ischemic retinopathy is a difficult disease to treat, although numerous drugs have been tried in the clinics. Coumarin was one of those tried as an anti-coagulant with a marginal efficacy. In this study, 15 coumarin derivs. were studied on the b-wave recovery in electroretinogram which is an indicator of the functional recovery of retina after ischemic insult. It was found that when positions 6, 7 and 8 were occupied by various functional groups, the b-wave recovery could be markedly enhanced. Single occupation of position 3 with any functional group would cause damaging effects to the anti-ischemic activity. It is concluded that some coumarin derivs. with two or all of these positions at 6, 7 and 8 occupied by certain functional groups could result in useful drugs for the treatment of ischemic retinopathy.Except for chemicals metioned above, 1846-76-0 and 93-35-6 are also used. .