Detail of "18532-87-1"

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The binding of the carcinostatic drugs cis-diamminedichloroplatinum(II) and pentaamminechlororuthenium(III) chloride with yeast transfer RNAPhe

The binding of the carcinostatic drugs cis-diamminedichloroplatinum(II) and pentaamminechlororuthenium(III) chloride with yeast transfer RNAPhe. Absence of binding to Watson-Crick base pairs. Rubin, J. R.; Sabat, M.; Sundaralingam, M. (Coll. Agric. Life Sci., Univ. Wisconsin, Madison, WI 53706, USA). Jerusalem Symp. Quantum Chem. Biochem., 16(Nucleic Acids), 471-7 (English) 1983. 18532-87-1 and 73-40-5 are also in the experiment. CODEN: JSQCA7. ISSN: 0075-3696. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) A crystallog. study on the interaction of cis-diamminedichloroplatinum(II) (cis-Pt) [15663-27-1], trans-diamminedichloroplatinum(II) (trans-Pt) [14913-33-8], and pentaamminechlororuthenium(III) chloride [18532-87-1] with yeast tRNAPhe was carried out. These carcinostatic drugs bound by monodentate ligation to N-7 of guanine [73-40-5] in nonhelical regions. Intrastrand crosslinks between adjacent guanines were not formed. In general, cis-Pt and trans-Pt complexes did not bind to Watson-Crick base pairs. .

Comparisons of p-bonding and hydrogen bonding in isomorphous compounds: [M(NH3)5Cl]Cl2 (M = Cr, Co, Rh, Ir, Ru, Os)

Comparisons of p-bonding and hydrogen bonding in isomorphous compounds: [M(NH3)5Cl]Cl2 (M = Cr, Co, Rh, Ir, Ru, Os). Hambley, Trevor W.; Lay, Peter A. (Dep. Inorg. Chem., Univ. Sydney, Sydney 2006, Australia). Inorg. Chem., 25(25), 4553-8 (English) 1986. CODEN: INOCAJ. ISSN: 0020-1669. DOCUMENT TYPE: Journal CA Section: 75 (Crystallography and Liquid Crystals) Section cross-reference(s): 78 The crystal and mol. structures of [M(NH3)5Cl]Cl2 (M = Ir, Os, Cr) were detd., and that with M = Ru was redetd. They are isomorphous with the known structures for M = Co and Rh (orthorhombic, space group Pnma, Z = 4). The lattice parameters and bond lengths for the structures are as follows: for Cr, a 13.441(3), b 10.504(2), c 6.755(1) ?, Cr-Cl 2.327(1), Cr-N(av) 2.074 ?; for Ru, a 13.418(3), b 10.501(2), c 6.777(1) ?, Ru-Cl 2.346(1), Ru-N(av) 2.103 ?; for Os, a 13.393(5), b 10. 1333-74-0 and 18532-87-1 are cas registry numbers of chemicals which are used as reagents here.50(2), c 6.774(1) ?, Os-Cl 2.369(2), Os-N(av) 2.113 ?; for Ir, a 13.393(1), b 10.483(2), c 6.768(1) ?, Ir-Cl 2.371(2), Ir-N(av) 2.088 ?. Final R values are 0.023, 0.020, 0.021, and 0.027 for the Cr, Ru, Os, and Ir complexes, resp. In the isomorphous series M = Co, Rh, Ir, Ru, Os, and Cr p-bonding in the M-Cl bond is more important for the d3 and the d5 ions than for the d6 ions. The strength of H bonding between the ammine hydrogens and the chloride anions increases with decreasing M-N bond lengths, while the strength of the intercomplex H bonding increases with increasing M-Cl bond lengths. The at. coordinates are given. .