Detail of "185517-21-9"

Reference

Synthesis of anti-Alzheimer (R)-arundic acid

Synthesis of anti-Alzheimer (R)-arundic acid. Pelotier, Beatrice; Holmes, Ta'id; Piva, Olivier (UMR CNRS 5181, Laboratoire de Chimie Organique, Photochimie et Synthese, Universite Claude Bernard Lyon 1, Villeurbanne 69622, Fr.). Tetrahedron: Asymmetry, 16(8), 1513-1520 (English) 2005 Elsevier B.V. CODEN: TASYE3. ISSN: 0957-4166. DOCUMENT TYPE: Journal CA Section: 23 (Aliphatic Compounds) The asym. synthesis of the anti-Alzheimer agent (R)-arundic acid (I) has been performed via a diastereoselective photodeconjugation reaction as the key-step. 185517-21-9 is the cas registry number. This chemical is also mentioned in this article. The synthetic approach involves a readily available chiral auxiliary, diacetone-D-glucose, and allows access to either enantiomer as illustrated by the synthesis of (S)-arundic acid. Both enantiomers were obtained in 88% ee using the same chiral auxiliary. .