Reference

Cold permanent wave composition

Cold permanent wave composition. Shiba, Kikuo (Nippon Rikagaku Yakuhin Co., Ltd., Japan). Ger. Offen. DE 2658424 23 Feb 1978, 7 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: A61K007-09. PRIORITY: JP 76-98897 19 Aug 1976. DOCUMENT TYPE: Patent CA Section: 62 (Essential Oils and Cosmetics) Cold permanent wave compns. comprise 3-10% cysteine alkyl esters and/or their salts, and additives, such as hair conditioners, penetrants, stabilizers and emulsifiers. The pH of the aq. soln. is 6.5-7.5. The lotion increases the natural shine and flexibility of the hair without the damaging effect of the usual thioglycolic acid treatment. The compns. can be easily applied to the hair at home by cold, warm or ironing method. For example, 10 g cysteine Me ester-HCl [18598-63-5] was dissolved in 100 mL H2O and the pH was adjusted to 10.3 with Na2CO3. The soln. was applied to washed and dried hair, which had no permanent treatment before, in such a way that hair on the rollers was satd. at 25° and left on for 25 min. The hair was then washed and dried.

Preparation of oxalylamino acid derivatives as proline and lysine hydroxylase inhibitors

Preparation of oxalylamino acid derivatives as proline and lysine hydroxylase inhibitors.. Baader, Ekkehard; Burghard, Harald; Guenzler-Pukall, Volkmar (Hoechst A.-G. 139419-72-0 and 18598-63-5 are also occured in this study., Germany). Ger. Offen. DE 4015255 A1 14 Nov 1991, 7 pp. (Germany). CODEN: GWXXBX. CLASS: ICM: C07C233-47. ICS: C07C323-59; A61K031-195; C07D207-16. APPLICATION: DE 90-4015255 12 May 1990. DOCUMENT TYPE: Patent CA Section: 34 (Amino Acids, Peptides, and Proteins) Section cross-reference(s): 1 RO2CCO-NR1CHR2CO2R3 [I; R, R3 = H, alkyl; R1 = H, alkyl; R2 = H, alkyl, alkoxy, CO2H, alkoxymethyl, aryl, SH, etc.] and their pharmaceutically acceptable salts, useful as fibrosuppressants and immunosuppressants, are prepd. MeO2CCOCl in CH2Cl2 was added to a soln. of alanine Me ester hydrochloride in CH2Cl2 contg. Et3N and (dimethylamino)pyridie at 0-10° and the mixt. allowed to react for 12 h at room temp. to give I [R = R2 = R3 = Me, R1 = H]. This had an IC50 of 0.35 mM against collagen-producing calvarial cells. .