Detail of "186320-20-7"

Reference

Preparation of peptide and non-peptide combinatorial libraries

Preparation of peptide and non-peptide combinatorial libraries. Baindur, Nand; Harris, Scott M.; Labroo, Virender M. (Zymogenetics, Inc., USA). PCT Int. Appl. WO 9640732 A1 19 Dec 1996, 67 pp. DESIGNATED STATES: W: AL, AM, AT, AU, AZ, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, NL, PT, SE.Some commonly used reagents like 186320-20-7 and 186320-30-9 are used in this experiment. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C07K001-00. APPLICATION: WO 1996-US9131 6 Jun 1996. PRIORITY: US 1995-482160 7 Jun 1995; US 1995-482231 7 Jun 1995; US 1995-483496 7 Jun 1995; US 1995-485391 7 Jun 1995. DOCUMENT TYPE: Patent CA Section: 34 (Amino Acids, Peptides, and Proteins) Section cross-reference(s): 27 Predetd. combinatorial libraries of non-peptide compds. A'-(BFU')m-(AA')n or A'-(AA')n-(BFU')m (A' = carboxylic acid; BFU' = bifunctional unit; AA' = amino acid; m = 1-10; n = 1-10) may be generated using a building block approach, a pseudopeptide approach or a scaffold approach. The resultant non-peptide compds. may feature aminooxy acids or bifunctional units. In addn., novel scaffolds I and II [X = COR, COR2, NHCOR2; Y = CO, CH2CO, CH2SO2, CH2PO2R< CH2C6H4CO, CH2C6H4SO2, CH2C6H4PO2R; R = H, (un)substituted alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl; R1 = COR, SO2R, PO2R2, CONR2, CSNR2, CO2R; R2 = OR, NR2, NRNR2, NROR; n = 1, 2] useful for generating combinatorial libraries are described. Thus, trifunctional scaffold III was prepd. from Boc-L-Hyp-OH, allyl bromide, and tert-Bu bromoacetate. .