Detail of "1866-43-9"

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Failure to elicit conditioned taste aversion by severe poisoning

Failure to elicit conditioned taste aversion by severe poisoning. Ionescu, Elisabeth; Buresova, Olga (Inst. Physiol., Czech. Acad. Sci., Prague, Czech.). Pharmacol., Biochem. Behav., 6(3), 251-4 (English) 1977. CODEN: PBBHAU. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) In an attempt to assess the universal validity of the conditioned taste aversion (CTA) paradigm, various types of poisoning (UC) were assocd. with the gustatory CS. Water deprived rats were habituated for 2 days to the drinking box, where water was available for 15 min. On day 3, access to the CS (0.1% saccharin [81-07-2] 15 min) was followed after 30 min by a sublethal dose of the poison (0.15 M LiCl 4% body wt; 0.1 M Na malonate [141-95-7], 1% body wt.; pyrrolopyrimidine drug BW 58-271 [1866-43-9], 15 mg/kg; NaCN 4 mg/kg; iodoacetate [64-69-7] 40 mg/kg; NaF 30 mg/kg gallamine triethiodide [65-29-2] 40 mg/kg). Rats injected with the last drug were maintained under artificial respiration until muscular paralysis disappeared. After 4 days of recovery, the water deprivation schedule was resumed on days 8 and 9. During the retention test on day 10 saccharin consumption dropped by 60% in the LiCl poisoned rats, but no CTA developed in animals poisoned by the pyrrolopyrimidine, gallamine, malonate and cyanide. CTA of intermediate intensity was evoked by iodoacetate and fluoride. The absence of CTA was not due to the amnesic effect of poisoning, since LiCl administration to NaCN poisoned rats produced CTA of usual intensity. Thus, CTA is not related to the overall severity of poisoning but rather to the effect of the poison on specific interoceptors.