Detail of "1867-66-9"

Reference

Failure of daily injections of ketamine hydrochloride to adversely alter menstrual cycle length, blood estrogen, and progesterone levels in the rhesus monkey

Failure of daily injections of ketamine hydrochloride to adversely alter menstrual cycle length, blood estrogen, and progesterone levels in the rhesus monkey. Channing, Cornelia P.; Fowler, Sandra; Engel, Bonnie; Vitek, Kveta (Dep. Physiol., Univ. Maryland Sch. Med., Baltimore, Md., USA). Proc. Soc. Exp. Biol. Med., 155(4), 615-19 (English) 1977. CODEN: PSEBAA. ISSN: 0037-9727. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The effects of daily administration of ketamine-HCl (I-HCl) [1867-66-9] (8-10 mg/kg) upon menstrual cycle length, incidence of ovulatory menstrual cycles, and blood estrogen and progesterone [57-83-0] levels throughout the cycle was studied in adult female rhesus monkeys. In phys. restrained control monkeys (25 cycles subjected to daily blood sampling) there were 14 or 25 or 56% ovulatory cycles, and in I-treated monkeys (32 menstrual cycles subjected to daily blood sampling) there were 28 of 32 or 88% ovulatory cycles. The length of the menstrual cycle was the same in both groups. The levels and time course of peripheral serum estrogen and progesterone levels were the same in the ovulatory cycles of both groups. In some of the control cycles (30%) and in some of the I-treated cycles (25%) there were luteal phases in which the preovulatory estrogen levels were normal and in which the luteal-phase progesterone levels were low and variable 6 to 8 days after the preovulatory surge. Thus the daily use of I does not significantly alter menstrual cycle length, or serum estrogen or progesterone levels throughout the menstrual cycle. I reduced the incidence of anovulatory cycles and premature menstrual induction probably by reducing the stress of restraining the monkey for the purpose of taking a blood sample.

Observations on ketamine hydrochloride as an anesthetic for alligators

Observations on ketamine hydrochloride as an anesthetic for alligators. Terpin, Kenneth M.; Dodson, Peter; Spotila, James R. (Sch. Vet. Med., Univ. Pennsylvania, Philadelphia, Pa., USA). Copeia, (1), 147-8 (English) 1978. CODEN: COPAAR. ISSN: 0045-8511. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Ketamine-HCl (I-HCl) [1867-66-9] (45-70 mg/kg, i.m.) was an effective, safe anesthetic for alligators and is effective for use in the field and the lab. Detailed time-course data on the duration of anesthesia are given.