Detail of "18679-90-8"

CAS Number:
18679-90-8
Name:
Butanoic acid,4-[[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]amino]-
Molecular Structure:
Formula:
C10H19 N O5
Molecular Weight:
0
Synonyms:
Butanoicacid, 4-[(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]-, (R)-; Butyric acid,4-(2,4-dihydroxy-3,3-dimethylbutyramido)-, D-(+)- (8CI); D-(+)-Homopantothenicacid; D-Homopantothenic acid; HOPan; Homopantothenic acid; Hopantenic acid
Density:
1.23g/cm³
Boiling Point:
556°Cat760mmHg
Flash Point:
290.1°C

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Studies on homopantothenic acid: Studies on homopantothenic acid. Nishizawa, Yoshito (Osaka Univ., Osaka, Japan). Med. J. Osaka Univ., 35(1-2), 41-50 (English) 1984. CODEN: MJOUAL. ISSN: 0030-6169. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacology) A review with 29 refs. on the pharmacol. and metab. of homopantothenic acid [18679-90-8] and its potential usefulness as an anticonvulsant.

Pantoyl-g-aminobutyric acid facilitates cholinergic function in the central nervous system: Pantoyl-g-aminobutyric acid facilitates cholinergic function in the central nervous system. Nakahiro, Masanobu; Fujita, Norihisa; Fukuchi, Isao; Saito, Kihachi; Nishimura, Tsuyoshi; Yoshida, Hiroshi (Sch. Med., Osaka Univ., Osaka 530, Japan). J. Pharmacol. Exp. Ther., 232(2), 501-6 (English) 1985. CODEN: JPETAB. ISSN: 0022-3565. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2 Pantoyl-g-aminobutyric acid (P-GABA) [18679-90-8] administered i.p. inhibited scopolamine- and atropine-induced locomotor activities in mice, but did not inhibit methamphetamine- and apomorphine-induced locomotor activities. In radiolabeled ligand binding expts., P-GABA did not inhibit the binding of [3H]quinuclidinyl benzilate, [3H]spiroperidol, and [3H]apomorphine to rat brain membranes, but inhibited that of [3H]muscimol. GABA [56-12-2] and P-GABA enhanced K+ (25 mM)-induced release of 3H-labeled acetylcholine [51-84-3] from slices of the cerebral cortex and hippocampus dose-dependently, and their effects were antagonized by bicuculline but not by tetrodotoxin. Apparently, P-GABA binds to GABA receptors causing enhanced cholinergic neurotransmission in the central nervous system. The results are discussed in relation to the clin. use of P-GABA in treatment of Alzheimer's disease and senile dementia of the Alzheimer type.