Detail of "186901-48-4"

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Cortistatin radioligand binding in wild-type and somatostatin receptor-deficient mouse brain

Cortistatin radioligand binding in wild-type and somatostatin receptor-deficient mouse brain.Several substances are used for example 186901-48-4 and 38916-34-6 which are their cas registry numbers. Spier, Avron D.; Fabre, Veronique; de Lecea, Luis (Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA). Regulatory Peptides, Volume Date 2005, 124(1-3), 179-186 (English) 2004 Elsevier B.V. CODEN: REPPDY. ISSN: 0167-0115. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Cortistatin-14 (CST-14) is a recently discovered member of the somatostatin family of neuropeptides. It shares 11 of its 14 amino acids with somatostatin-14 (SRIF-14). In the present study, binding sites for cortistatin-14 in the mouse brain were examd. and compared to those for somatostatin using iodinated cortistatin-14 and iodinated somatostatin-14. By in vitro receptor autoradiog., high densities of cortistatin-14 and somatostatin-14 specific binding sites were detected in the cortex, hippocampal formation, basolateral amygdala and medial habenula. Unlabeled 100 nM cortistatin-14 inhibited iodinated somatostatin-14 binding in the hippocampus, but not in the cortex or amygdaloid nuclei. In somatostatin receptor subtype-2 knock-out (KO) mice, autoradiog. iodinated somatostatin-14 binding was obsd. in the hippocampus and habenula but was removed in the cortex and amygdaloid nuclei, specific iodinated cortistatin-14 binding sites were found in the hippocampus, habenula and throughout the cortex. We conclude that the somatostatin receptor subtype-2 is responsible for somatostatin binding in cortical and amygdaloid regions and that cortistatin predominantly interacts with the same receptors as somatostatin. .