Detail of "18713-58-1"

CAS Number:
18713-58-1
Name:
1-Propanone,1-(4-chlorophenyl)-2-methyl-
Molecular Structure:
Formula:
C10H11 Cl O
Molecular Weight:
182.66
Synonyms:
Propiophenone,4'-chloro-2-methyl- (6CI,7CI,8CI); 1-(4-Chlorophenyl)-2-methyl-1-propanone;4-Chlorophenyl isopropyl ketone; 4'-Chloro-2-methylpropiophenone;4'-Chloroisobutyrophenone; p-Chloroisobutyrophenone; p-Chlorophenyl isopropylketone
Density:
1.098g/cm³
Boiling Point:
264.1°Cat760mmHg
Flash Point:
137°C
Safety:
Moderately toxic by intraperitoneal route. A flammable liquid. When heated to decomposition it emits toxic vapors of Cl⁻. Details

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Azole derivatives: Azole derivatives. Schaub, Fritz (Sandoz-Patent-G.m. 18713-58-1 which is the cas registry number of some chemical is mentioned.b.H., Fed. Rep. Ger.). Ger. Offen. DE 3337937 A1 3 May 1984, 24 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C07D249-08; C07D233-60; A01N043-50; A01N043-64; A61K031-41; A61K031-415; C07C049-333; C07D303-08. APPLICATION: DE 83-3337937 19 Oct 1983. PRIORITY: CH 82-6300 28 Oct 1982. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1, 5 (Cyclopropylalkyl)azoleethanols I [R = (un)substituted Ph; R1, R2 = H, alkyl; R3 - R5 = H, alkyl, halo; R6 = Br, Cl, F; R7 = H, R6; X = CH, N; Z = CH2, alkylidene, bond] were prepd. Thus, 4-ClC6H4COCHMe2 was allylated to give 4-ClC6H4COCMe2CH:CH2. This underwent cycloaddn. with Cl2C: to give the cyclopropane deriv. which was treated with C12H25S+Me2 MeOSO3- to give the oxirane II. This was treated with 1H-1,2,4-triazole, cleaving the oxirane ring, to give I (R = 4-ClC6H4, R1 = R2 = Me, R3 - R5 = H, R6 = R7 = Cl, X = N, Z = CH2) (III). In mice 12.5 mg III/kg/day orally for 4 days gave complete control of Candida albicans infection. .

Substituted diazolylalkylcarbinols and their use as antimycotic agents: Substituted diazolylalkylcarbinols and their use as antimycotic agents. Elbe, Hans Ludwig; Regel, Erik; Buechel, Karl Heinz; Schaller, Klaus; Plempel, Manfred (Bayer A.-G. , Fed. Rep. Ger.). Ger. Offen. DE 3307218 A1 6 Sep 1984, 46 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C07D249-08; C07D403-06; A61K031-41; A61K031-415. APPLICATION: DE 83-3307218 2 Mar 1983. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1, 63 The title compds [I; R = (un)substituted Ph, R3R4R5C; R1 = H, alkyl; R2 = alkyl, alkenyl, alkynyl, (un)substituted PhCH2; R3, R4 = alkyl; R3R4 = alkylene; R5 = alkyl, alkenyl, (un)substituted Ph, PhO, PhS, PhCH2O, PhCH2S; X, X1 = CH, N] were prepd. Thus, 4-ClC6H4COCHMe2 was brominated and condensed with 1H-1,2,4-triazole (II) to give triazolylmethyl ketone III. This was converted to an oxirane deriv. by treatment with Me3S+ I- and condensed with II to give I (R = 4-ClC6H4, R1 = H, R2 = Me, X = X1 = N) (IV). 18713-58-1 is just another one chemical used in this study. In mice infected with Candida albicans 2 ′ 10-50 mg IV/kg orally gave 90% survival after 6 days compared to 5% survival for controls. .