Reference

Luliconazole, a new topical antifungal agent

All Rights Reserved. Luliconazole, a new topical antifungal agent. Majima, Toshiro (Japan). Kagaku Ryoho no Ryoiki, 22(5), 815-821 (Japanese) 2006 Iyaku Janarusha. CODEN: KRRYEI. ISSN: 0913-2384. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacology) Section cross-reference(s): 63 A review, discussing action mechanism and clin. pharmacol.In this experiment, several chemicals are used like 187164-19-8 of luliconazole, a new topical antifungal agent against mycosis. .

In vitro antifungal activity of luliconazole against clinical isolates from patients with dermatomycosis

All Rights Reserved. In vitro antifungal activity of luliconazole against clinical isolates from patients with dermatomycosis. Koga, Hiroyasu; Tsuji, Yuri; Inoue, Kazuyoshi; Kanai, Kazuo; Majima, Toshiro; Kasai, Tatsuya; Uchida, Katsuhisa; Yamaguchi, Hideyo ( Research Center, Nihon Nohyaku Co., Ltd. 345 Oyamada-cho, Kawachi-Nagano, Osaka 586-0094, Japan). Journal of Infection and Chemotherapy, 12(3), 163-165 (English) 2006 Springer Tokyo. CODEN: JICHFN. ISSN: 1341-321X. DOCUMENT TYPE: Journal CA Section: 10 (Microbial, Algal, and Fungal Biochemistry) Section cross-reference(s): 14 The in vitro antifungal activity of luliconazole, a novel topical imidazole, against pathogenic fungi implicated in dermatomycosis was studied. A total of 91 clin. isolates, consisting of 59 Trichophyton rubrum isolates, 26 T. mentagrophytes isolates, 1 Epidermophyton floccosum isolate, and 5 Candida albicans isolates were tested by the broth microdilution method, employing lanoconazole, terbinafine, and bifonazole as ref. drugs. The min. inhibitory concns. (MICs) of luliconazole against T. rubrum and T. mentagrophytes were in the range of 0.00012-0.004 mg/mL and 0.00024-0.002 mg/mL, resp. 187164-19-8 and 91161-71-6 are cas registry numbers of chemicals which are used as reagents here. The MIC90 of luliconazole for these two species of dermatophytes was the same, at 0.001 mg/mL, and these values were 4 times, 30 times, and more than 1000 times lower than those of lanoconazole, terbinafine, and bifonazole, resp. Similarly, the 1 isolate of E. floccosum tested was inhibited by luliconazole with an MIC of 0.001 mg/mL. Luliconazole also proved to be very potent against C. albicans (MIC range, 0.031-0.25 mg/mL), nearly on par, in terms of efficacy, with lanoconazole (0.063-0.25 mg/mL) and more potent than terbinafine (2->64 mg/mL) and bifonazole (0.5-4 mg/mL). These results showed that luliconazole was very potent in vitro against pathogenic fungi isolated from patients with dermatomycosis, and these findings emphasized the utility of luliconazole for the topical management of this condition. .