Detail of "1878-94-0"

CAS Number:
1878-94-0
Name:
Acetic acid,2-(4-iodophenoxy)-
Superlist Name:
4-Iodophenoxyacetic acid
Molecular Structure:
Formula:
C₈H₇IO₃
Molecular Weight:
278.05
Synonyms:
Aceticacid, (4-iodophenoxy)- (9CI);Acetic acid, (p-iodophenoxy)- (6CI,7CI,8CI);p-Iodophenoxyacetic acid;
EINECS:
217-531-0
Density:
1.896 g/cm³
Melting Point:
154-157 °C(lit.)
Boiling Point:
358.5 °C at 760 mmHg
Flash Point:
170.6 °C
Appearance:
white to light yellow powder
Risk Codes:
36/37/38
Safety:
24/25 Details

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Effects of 4-iodophenoxyacetic acid on the growth and development of gametophytes and young sporophytes of Laminaria and its application in culturing summer sporelings: Effects of 4-iodophenoxyacetic acid on the growth and development of gametophytes and young sporophytes of Laminaria and its application in culturing summer sporelings. Miao, Guorong; Chen, Jiaxing; Liu, Qishun (Shandong Coll. Oceanogr., Qingdao, Peop. Rep. China). Hydrobiologia, 116-117, 478-80 (English) 1984. CODEN: HYDRB8. ISSN: 0018-8158. DOCUMENT TYPE: Journal CA Section: 5 (Agrochemical Bioregulators) 4-Iodophenoxyacetic acid (I) [1878-94-0] at 1-100 mg/L had no significant effect on the rate of formation of oogonia in female gametophytes of L. japonica; at 250 mg/L this rate decreased to 19% and at 500 mg/L, the gametophytes failed to form gametes. I (1-5 mg/L) promoted the growth of the sporophores, but this growth was inhibited at >25 mg/L. The inhibited gametophytes regained reproductive capability when returned to culture in ordinary media.

Preparation of podophyllotoxin derivatives for use in pharmaceutical compositions for the treatment of cancer: Preparation of podophyllotoxin derivatives for use in pharmaceutical compositions for the treatment of cancer. Yang, Li-Xi (USA ). U.S. Pat. Appl. Publ. US 2005004169 A1 6 Jan 2005,24 pp. (English). (United States of America). CODEN: USXXCO. CLASS: ICM: A61K031-452. ICS: A61K031-4025; A61K031-365; C07D493-02. APPLICATION: US 2003-612240 1 Jul 2003. DOCUMENT TYPE: Patent CA Section: 26 (Biomolecules and Their Synthetic Analogs) Section cross-reference(s): 1, 63 Podophyllotoxin derivs., such as I [R = CO-(CH2)m-X-R1; m = 0-10; X = S, O, N, bond; R1 = substituted Ph, substituted cycloalkyl having 3 to 7 carbons forming the ring, optionally substituted fused heterocycle, naphthyl, anthraquinone, hemisuccinic acid etc.], were prepd. 1878-94-0 and 819805-42-0 are also in the experiment. for use as antitumor agents. When combined with suitable pharmaceutical excipients, these compds. are useful for treating various types of cancer. Thus, podophyllotoxin I (R = H) underwent an acylation reaction with F-4-C6H4OCH2CO2H using EDCI and DMAP in CH2Cl2 to give 4-(fluorophenoxyacetyl)podophyllotoxin I (R = COCH2OC6H4-4-F). The prepd. podophyllotoxin derivs. were assayed in vitro for inhibition of growth of HCT116 cells and assayed in vivo for antitumor activity in C3H/HeJ mice bearing MTG-B tumors. .