Reference

First derivative spectrophotometric determination of certain drugs in two-component mixtures

First derivative spectrophotometric determination of certain drugs in two-component mixtures. Korany, M. A.; Wahbi, A. M.; Elsayed, M. A.; Mandour, S. (Fac. Pharm., Alexandria Univ., Egypt). Anal. Lett., 17(B12), 1373-89 (English) 1984. CODEN: ANALBP. ISSN: 0003-2719. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Four 2-component drugs were analyzed by 1st-deriv. spectrometry, which eliminated formulation matrix interferences. Suppositories contg. acepifylline [18833-13-1] and phenobarbitone [50-06-6] (4:1) were melted and dissolved in hot EtOH. Injections contg. procaine [59-46-1] (as hydrochloride) and caffeine [58-08-2] were dild. with H2O. Tablets contg. sulfamethoxazole [723-46-6] and trimethoprim [738-70-5] and those contg. amidopyrine [58-15-1] and phenylbutazone [50-33-9] were dissolved in EtOH and dild. with 0.1N HCl and pH 7 citrate-phosphate buffer, resp. Phenobarbitone and acepifylline in 0.1N NaOH were measured at 262 and 283 nm, caffeine and procaine in H2O at 282 and 306 nm, sulfamethoxazole and trimethoprim in pH 7 buffer at 237 and 265 nm and phenylbutazone and amidopyrine in 0.1N at 245 and 267 nm.

Application of first derivative spectrometry to the determination of certain drugs in single component dosage forms

Application of first derivative spectrometry to the determination of certain drugs in single component dosage forms. Korany, M. A.; Wahbi, A. M.; Elsayed, M. A.; Mandour, S. (Fac. Pharm., Univ. Alexandria, Alexandria, Egypt). Farmaco, Ed. Prat., 39(7), 243-52 (English) 1984. CODEN: FRPPAO. ISSN: 0430-0912. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Acepifylline [18833-13-1], cinchocaine [85-79-0], oxyphenbutazone [129-20-4], phenylbutazone [50-33-9] and saccharin [81-07-2] were detd. in pharmaceuticals by 1st deriv. UV spectrophotometry using 2 wavelengths 257 and 283 for acepifylline and 249 and 336 nm for cinchocaine and single wavelengths 270, 280, and 285 nm, resp. for the latter 3 compds. There was no interference from irrelevant absorption from the formulations.