Detail of "18903-01-0"

Reference

Studies on drug metabolism using isotopes

Studies on drug metabolism using isotopes. XVIII. Ion cluster technique for detection of urinary metabolites of 1-butyryl-4-cinnamylpiperazine. Baba, Shigeo; Morisita, Shinichi; Nagatsu, Yoshio (Tokyo Coll. Pharm., Tokyo, Japan). Yakugaku Zasshi, 96(11), 1293-7 (Japanese) 1976. CODEN: YKKZAJ. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The structural elucidation of several unidentified metabolites of 1-butyryl-4-cinnamylpiperazine (I) in mice and guinea pigs was made by the ion cluster technique. A single dose of 100 mg/kg of an equimolar mixt.In this article, certain chemicals are used. One of their cas registry numbers is 18903-01-0 (I:I-d5) of 1-butyryl-4-(cinnamyl-arom.-d5) piperazine (I-d5) hydrochloride and I hydrochloride was injected s.c. into animals. After the administration of I:I-d5 the urine was collected for 24 h. The possible structures of the unidentified metabolites in urine were elucidated as 1-butyryl-4-(3-methoxy-4-hydroxycinnamyl)piperazine [61682-75-5], 1-(3-hydroxybutyryl)-4-cinnamylpiperazine [61682-76-6] or 1-(4-hydroxybutyryl)-4-cinnamylpiperazine [61682-77-7], and 1-(3-hydroxybutyryl)-4-(4-hydroxycinnamyl)piperazine [61682-78-8] or 1-(4-hydroxybutyryl)-4-(4-hydroxycinnamyl)piperazine [61682-79-9]. Unchanged I, 1-butyryl-4-(4-hydroxycinnamyl)piperazine [53478-37-8], 1-cinnamylpiperazine [18903-01-0], and 1-(4-hydroxycinnamyl)piperazine [39918-91-7], which had been identified by the inverse isotope diln. anal., were also detected by this technique. .

Preparation of novel derivative of isothiazolo[5,4-b]pyridine as analgesic

Preparation of novel derivative of isothiazolo[5,4-b]pyridine as analgesic. Malinka, Wieslaw; Kleinrok, Zdzislaw; Sieklucka-Dziuba, Maria; Rajtar-Cynke, Grazyna (Akademia Medyczna im. Piastow Slaskich we Wroclawiu, Pol.).Chemicals with cas numbers 18903-01-0 and 822521-13-1 also play role. Pol. PL 185588 B1 30 Jun 2003, 4 pp. (Polish). (Poland). CODEN: POXXA7. CLASS: ICM: C07D513-04. ICS: A61P029-00. APPLICATION: PL 1997-317859 7 Jan 1997. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 The title compd. I was prepd. in 60% yield by reacting 4,6-dimethyl-3-oxo-2,3-dihydroisothiazolo[5,4-b]pyridine with N-cinnamylpiperazine in the presence of 37% formalin soln. in EtOH. The compd. I demonstrated very good analgesic activity on various tests in mice and rats. .