Reference

Substituted 1,3-dihydrospiro[isobenzofuran]s for tranquilizing and treating pain

Substituted 1,3-dihydrospiro[isobenzofuran]s for tranquilizing and treating pain. Bauer, Victor J.; Kosley, Raymond W., Jr. (American Hoechst Corp., USA). U.S.Several reagents with their cas registry numbers 18982-54-2 and 75-36-5 are used here. US 3985889 12 Oct 1976, 10 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K031-445. NCL: 424267000. APPLICATION: US 73-424080 12 Dec 1973. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Fifteen ketones I (R = Me, Bu, PhCH2CH2, (CH2)3CH(C6H4F-4)2, (CH2)3COC6H4F-4, (CH2)2COPh, allyl, CH2CH:CMe2, (CH2)2CHPhOH, Ph2CHOCH2CH2; R1 = H, MeO; R2 = H, F, MeO; R1R2 = methylenedioxy; n = 0, 1) and spiro compds. II [R = Me, cyclopropylmethyl, (CH2)3COC6H4F-4, Ac, (CH2)3CH(C6H4F-4)2], effective as tranquilizers and analgesics, were prepd. Thus, reaction of o-BrC6H4CO2H and HOCH2CMe2NH2 gave o-BrC6H4NHCMe2CH2OH, which was cyclized with SOCl2 to give 2-(o-bromophenyl)-4,4-dimethyl-2-oxazoline (III). The Grignard reagent from III was treated with 1-methyl-4-piperidone to give IV, which was treated with acid to give I (R = Me, R1 = R2 = H, n = 1). .

A modular approach to marine macrolide construction

A modular approach to marine macrolide construction. 1. An enantiocontrolled route to the C1-C12 (AB) spiroacetal sector. Paquette, Leo A.; Zuev, Dmitry (Evans Chem. Laboratories, Ohio State Univ., Columbus, OH 43210, USA). Tetrahedron Letters, 38(29), 5115-5118 (English) 1997 Elsevier. CODEN: TELEAY. ISSN: 0040-4039. 18982-54-2 which is the cas registry number of some chemical is mentioned. DOCUMENT TYPE: Journal CA Section: 26 (Biomolecules and Their Synthetic Analogs) A practical approach to a desymmetrized, enantiomerically pure AB spiroacetal ring component (I) of altohyrtin A and its congeners is detailed.Except for chemicals metioned above, 18982-54-2 is also used. ..