Detail of "1908-11-8"

Reference

Surface tension lowering and dissolution rate of hydrocortisone from solid solutions of selected n-acyl esters of cholesterol

Surface tension lowering and dissolution rate of hydrocortisone from solid solutions of selected n-acyl esters of cholesterol. Kim, Kwon Ho; Jarowski, Charles I. (Coll. Pharm. Allied Health Prof., St. John's Univ., Jamaica, N. Y., USA). J. Pharm. Sci., 66(11), 1536-40 (English) 1977. CODEN: JPMSAE. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The dissoln. of hydrocortisone (I) [50-23-7] into simulated intestinal fluid from lipid delivery systems followed second-order kinetics. As the ratio of I to lipid was increased from 1:1 to 1:6, the dissoln. rate decreased. Solvent deposition of solid solns. of I and lipid on lactose resulted in the enhancement of the dissoln. rate. For the 1:1 I-lipid solid solns., the rank order of the dissoln. rate was I-cholesteryl stearate [35602-69-8], I, I-cholesterol [57-88-5] I-cholesteryl acetate [604-35-3], I-cholesteryl palmitate [601-34-3], I-cholesteryl n-butyrate [521-13-1], I-cholesteryl laurate [1908-11-8], and I-cholesteryl n-decylate [1183-04-6]. A direct correlation was found between the dissoln. rate of I and the surface tension lowering of simulated intestinal fluid by the corticoid and various lipids.

Hair growth-stimulating preparations with low-temperature stability

Hair growth-stimulating preparations with low-temperature stability. Iwao, Shuji (Lion Corp., Japan). Jpn. Kokai Tokkyo Koho JP 04005219 A2 9 Jan 1992 Heisei, 7 pp. (Japan).In this study， 86596-00-1 and 1908-11-8 are also used. CODEN: JKXXAF. CLASS: ICM: A61K007-06. APPLICATION: JP 90-107051 23 Apr 1990. DOCUMENT TYPE: Patent CA Section: 62 (Essential Oils and Cosmetics) The title prepns. contain odd-numbered satd. fatty acids, their salts, odd-numbered aliph. alcs., and/or their derivs. and lipid derivs. Lipid derivs. improve the low.-temp. stability of the prepn. A compn. (0. 2mL) contg. glycerin monopentadecanoate 3.0, gangliosides 0.5, sorbitan monolaurate 5.0 wt.%, and EtOH balance was applied to a shaven part of back of rabbit twice a wk for 30-60 days to accelerate the change of telogen hair to growing hair. The compn. was stored at -5° for 1 mo without sepn. or crystn. A hair tonic contained pentadecanoic acid glyceride (mono-/di- = ) 5.0, galactose-b-1-ceramide 3.0, dl-a-tocopherol acetate 0.3, b-glycyrrhetinic acid 0.1, hinokitiol 0.01, swertia ext. 0.3, vitamin B12 0.01, pantothenylethyl alc. 0.2, benzyl nicotinate 0.003, isopropylmethylphenol 0.1, sorbitan monolaurate 6.0, perfume 0.4 wt.%, and EtOH balance. .