Detail of "1909-91-7"

Reference

Isolation and identification of two new diterpene acids from the green cones of cypress (Cupressus sempervirens L

Isolation and identification of two new diterpene acids from the green cones of cypress (Cupressus sempervirens L.). Neocupressic acid III and isocupressic acid. Balansard, G.; Hannan, A.; Bernard, P.; Susplugas, P.; Boukef, K. (Lab.Some commonly used reagents like 61505-29-1 and 1909-91-7 are used in this experiment. Matiere Med. Pharm. Galenique, Fac. Pharm., Marseille, Fr.). Trav. Soc. Pharm. Montpellier, 36(3), 219-29 (French) 1976. CODEN: TSPMA6. DOCUMENT TYPE: Journal CA Section: 11 (Plant Biochemistry) Section cross-reference(s): 30 Neocupressic acid II (I) and isocupressic acid were isolated from C. sempervirens by column and thin-layer chromatog. and identified by m.p., IR, NMR, UV, and mass spectra, anal. reactions, and elemental anal. .

Isocupressic acid and related diterpene acids from Pinus ponderosa as abortifacient compounds in cattle

Isocupressic acid and related diterpene acids from Pinus ponderosa as abortifacient compounds in cattle. Gardner, D. R.; Panter, K. E.; Molyneux, R. J.; James, L. F.; Stegelmeier, B. L.; Pfister, J. A. (USDA/ARS/Poisonous Plant Research Laboratory, Logan, UT 84341, USA). Journal of Natural Toxins, 6(1), 1-10 (English) 1997 Alaken. CODEN: JNTOER. ISSN: 1058-8108. DOCUMENT TYPE: Journal; General Review CA Section: 4 (Toxicology) A review with 20 refs.Several substances like 1909-91-7 may be metioned in this study. Consumption of Pinus ponderosa needles by cattle in late stages of pregnancy is known to cause abortions. We recently demonstrated that isocupressic acid, a diterpene acid from the pine needles, was an active abortifacient compd. when given orally to pregnant cattle. Acetyl and succinyl derivs. of isocupressic acid are also active abortifacients in cattle, apparently after ruminal activation by ester hydrolysis to isocupressic acid, following oral administration. Acetyl- and succinyl-isocupressic acid have been shown to be rapidly metabolized to isocupressic acid in vitro in active rumen fluid with 50% conversion after two to four hours, resp. I.v. infusion of isocupressic acid induced abortion in three of four cows while i.v. infusion of acetyl- and succinyl-isocupressic acid failed to induce abortion. Isocupressic acid is rapidly metabolized by the post-absorptive system to structurally similar diterpene acid compds., including the predominant serum metabolite agathic acid. .