Detail of "1918-79-2"

Suppression of calcific fibrous-fatty plaque formation in rabbits by agents not affecting elevated serum cholesterol levels: Suppression of calcific fibrous-fatty plaque formation in rabbits by agents not affecting elevated serum cholesterol levels. The effect of thiophene compounds. Chan, Catherine T.; Wells, Herbert; Kramsch, Dieter M. (Boston Univ. Med. Cent., Boston, Mass., USA). Circ. Res., 43(1), 115-25 (English) 1978. CODEN: CIRUAL. ISSN: 0009-7330. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) 2-Thiophenecarboxylic acid (I) [527-72-0], 5-methyl-2-thiophenecarboxylic acid (II) [1918-79-2] and 5-bromo-2-thiophenecarboxaldehyde (III) [4701-17-1] normalized the elevated serum Ca but not the cholesterol [57-88-5] levels, and effectively inhibited all aspects of the atherosclerotic process as detd. morphol. and biochem. in rabbits fed a fibrogenic atherogenic diet. The order of effectiveness was: II > III > I. No bone resorption occurred in the treated groups. The normalizing effects of the thiophene compds. on serum P levels were not significant at the dosages used.

Synthesis of some alkyl-substituted 1,3-dienecarboxylic acids from the derivatives of 2,5-dihydrothiophene-2-carboxylic acids: Synthesis of some alkyl-substituted 1,3-dienecarboxylic acids from the derivatives of 2,5-dihydrothiophene-2-carboxylic acids. Konstantinova, T. G.; Moiseenkov, A. M.; Gul'tyai, V. P.Chemicals with cas numbers 86610-35-7 and 1918-79-2 also play role. (Inst. Org. Khim. im. Zelinskogo, Moscow, USSR). Izv. Akad. Nauk SSSR, Ser. Khim., (9), 2101-4 (Russian) 1983. CODEN: IASKA6. ISSN: 0002-3353. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Electrochem. redn. of I (R = Me, pentyl) in 2M LiOH gave II (R1 = H) which were esterified by CH2N2 or EtOH-H2SO4 to give II (R = R1 = Me; R = pentyl, R1 = Et). Oxidn. of II by m-ClC6H4C(O)OOH gave the sulfones III which were refluxed 3 h in PhMe to give RCH:CHCH:CHCO2R1. Addnl. obtained was Me(CH2)4CH:CHCH:CHCONHCHMeEt. .