Reference

Interferences of prazosin on the binding of dicumarol with serum proteins

Interferences of prazosin on the binding of dicumarol with serum proteins. Crispino, A.; Di Carlo, F. (Ist. Farmacol. Ter. Sper., Univ. Torino, Turin, Italy). Farmaco, Ed. Prat., 33(1), 22-5 (English) 1978. CODEN: FRPPAO. ISSN: 0430-0912. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The capacity of a new antihypertensive agent prazosin-HCl (I) [19237-84-4] to bind with bovine serum albumin was studied. I had poor binding capacity and did not interfere with the binding of dicumarol [66-76-2] or other drugs.

The effect of food intake on the plasma kinetics and toleration of prazosin

The effect of food intake on the plasma kinetics and toleration of prazosin. Verbesselt, R.; Mullie, A.; Tjandramaga, T. B.; De Schepper, P. J.; Dessain, P. (Dep. Pharmacol., Univ. Leuven Sch. Med., Louvain, Belg.). Acta Ther., 2(1), 27-39 (English) 1976. CODEN: ACTTDZ. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) After oral administration of Minipress (prazosin) (I) [19237-84-4] (2 mg) to fasting and nonfasting healthy volunteers, there were no significant differences in the plasma I concns. between the 2 groups. The plasma I concns. varied significantly among individuals in both the fasting and nonfasting volunteers. The toxic side effects of I, however, were markedly less in the nonfasted than in the fasted subjects. Dizziness was the most predominant side effect obsd. Repeated administration at short intervals caused less side effects.