Detail of "19313-28-1"

CAS Number:
19313-28-1
Name:
Prostan-1-oic acid,11,15-dihydroxy-9-oxo-, (11a,15S)-
Molecular Structure:
Formula:
C20H36 O5
Molecular Weight:
356.5
Synonyms:
Cyclopentaneheptanoicacid, 3-hydroxy-2-(3-hydroxyoctyl)-5-oxo-, stereoisomer (8CI);(15S)-Dihydroprostaglandin E1; 11,15-Dihydroxy-9-ketoprostanoic acid; 11a,15-Dihydroxy-9-oxoprostanoicacid; 13,14-Dihydro-PGE1; 13,14-Dihydroprostaglandin E1; Dihydro-PGE1;Dihydroprostaglandin E1; PGE0; U 23307; prostaglandin E0
Density:
1.075g/cm³
Boiling Point:
541.4°Cat760mmHg
Flash Point:
295.3°C

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Prostaglandin derivative-containing drug formulations with blood pressure lowering activity: Prostaglandin derivative-containing drug formulations with blood pressure lowering activity. (Upjohn Co., USA). Neth. Appl. NL 7702818 30 Jun 1977, 10 pp. Division of Neth. 66 11,478. (Dutch). (Netherlands). CODEN: NAXXAN. CLASS: IC: A61K031-19. PRIORITY: US 65-480107 16 Aug 1965. DOCUMENT TYPE: Patent CA Section: 2 (Hormone Pharmacology) Section cross-reference(s): 24 Prostaglandin derivs. I (R = H, alkyl, or cation) have antihypertensive and hypolipemic activity. For example, 100 mg 11a,15-dihydroxy-9-oxoprostanoic acid [19313-28-1] was dehydrated by heating at 60° for 18 h in AcOH-H2O (9 mL:1 mL) to form 15-hydroxy-9-oxoprost-10-enoic acid [28834-62-0].

Reversal of noradrenaline-induced constriction of hamster cheek pouch arterioles by prostaglandins and their metabolites: Reversal of noradrenaline-induced constriction of hamster cheek pouch arterioles by prostaglandins and their metabolites. Westwick, J.; Lewis, G. P. (Inst. Basic Med. Sci., R. Coll. Surg., London, Engl.). Bibl. Anat., 16(Recent Adv. Clin. Microcirc. Res.), 466-8 (English) 1977. CODEN: BIANA6. ISSN: 0067-7833. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) In the everted hamster cheek pouch, PGE1 (I) [745-65-3] dose-dependently reversed the noradrenaline (II) [51-41-2]-induced constriction of arterioles. The relative potencies of other compds. for reversal of I-induced arteriolar constriction were PGE2 [363-24-6] > 13,14-dihydro-PGE2 [363-22-4], > PGE1 > 13,14-dihydro-PGE1 [19313-28-1] > bradykinin [58-82-2]. Apparently, prostaglandins are potent vasodilators in this model system.