Detail of "19316-85-9"

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Supplier:Berry & Associates, Inc. [ United States]

610 Integral
610

Tel:800 357-1145

Address:2434 Bishop Circle East Dexter, MI 48130 USA

Supplier:Okeanos Tech Jiangsu Co. Ltd. [ China (Mainland)]

610 Integral
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Tel:+86-510-86636249

Address:No. 2 Runhua Road, Ligang, Jiangyin, Jiangsu, China

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Synthesis and in vitro antiviral activity of 3'-O-acyl derivatives of 5'-amino-5'-deoxythymidine: potential prodrugs for topical application: Synthesis and in vitro antiviral activity of 3'-O-acyl derivatives of 5'-amino-5'-deoxythymidine: potential prodrugs for topical application. Lin, Tai Shun (Sch. Med., Yale Univ., New Haven, CT 06510, USA). J. Pharm. Sci., 73(11), 1568-71 (English) 1984. CODEN: JPMSAE. ISSN: 0022-3549. DOCUMENT TYPE: Journal CA Section: 33 (Carbohydrates) Section cross-reference(s): 1 Ten title compds. 19316-85-9 are also occured in this study. I [R = Me(CH2)n, Me2CH, Me3CCH2, Ph; n = 0-6] were prepd. by acylation of 5'-azido-5'-deoxythymidine, followed by catalytic hydrogenation. All the derivs. showed activity against HSV-1 virus similar to the parent compd., except the arom. and the highly branched aliph. esters (I; R = Me3CCH2, Ph) which were less active. Owing to their markedly improved lipophilicity, these compds. are believed to penetrate the biol. membranes more easily, and thus, would be more effective for the topical treatment of cutaneous herpes virus infections. .