Reference

Identification of synthetic dyes in some dragees produced by Polfa

Identification of synthetic dyes in some dragees produced by Polfa. Sykulski, Jerzy; Jaskulska, Teresa (Inst. Technol. Chem. Lek., Akad. Med., Lodz, Pol.). Farm. Pol., 40(2), 91-3 (Polish) 1984. CODEN: FAPOA4. ISSN: 0014-8261. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Five dyes, Tartrazine G [1934-21-0], Yellow Orange S [2783-94-0], Cochineal Red [56509-72-9], Amaranth [915-67-3], and Indigotin [482-89-3], used for tablet staining, were sepd. by TLC on cellulose MN 300 CM in a NaCl-water-conc. NH4OH (2:) system. The dyes were extd. from the tablets by dil. HCl, adsorbed on a layer of Al2O3, eluted with 0.5% NH4OH, the ext. was evapd. to dryness on water bath, and aq. solns. of the dyes were applied on thin layer of cellulose. The method allows fast and reliable identification of dyes from colored tablets.

The effect of tartrazine on histamine release from rat peritoneal mast cells

The effect of tartrazine on histamine release from rat peritoneal mast cells. Safford, R. J.; Goodwin, B. F. J. (Colworth Lab., Unilever Ltd., Sharnbrook/Bedford MK44 1LQ, UK). Int. J. Immunopharmacol., 6(3), 233-40 (English) 1984. CODEN: IJIMDS. ISSN: 0192-0561. DOCUMENT TYPE: Journal CA Section: 17 (Food and Feed Chemistry) Section cross-reference(s): 15 The release of histamine [51-45-6] from purified rat peritoneal mast cells induced by specific antigen (egg albumin), compd. 48/80 and Ca ionophore A23187 was modified by tartrazine [1934-21-0]. Histamine release induced by 48/80 and antigen was inhibited by the presence of 10-5 to 10-2M tartrazine. The inhibitory effect on egg albumin-induced histamine release was maximal when the tartrazine was added simultaneously with egg albumin, and was reduced by increased preincubation of the cells with tartrazine. Tartrazine had a small inhibitory effect on ionophore-induced release at high concns., but augmented histamine release at tartrazine concns. of 10-3 and 10-4M. Augmentation of ionophore-induced release was maximal at 0-5 min preincubation of the cells with tartrazine.