Reference

The activity of eight antimicrobial compounds, including three nitroimidazole compounds, against Bacteroides sp

The activity of eight antimicrobial compounds, including three nitroimidazole compounds, against Bacteroides sp. Wise, R.; Bedford, K. A.; Andrews, Jennie (Dep. Med. Microbiol., Dudley Road Hosp., Birmingham, Engl.). Chemother., Proc. Int. Congr. Chemother., 9th, Meeting Date 1975, Volume 1, 235-41. Edited by: Williams, John David; Geddes, Alexander M. Plenum: New York, N. Y. 50-59-9 and 25953-19-9 which are cas registry numbers are also used here. (English) 1976. CODEN: 35DFA6. DOCUMENT TYPE: Conference CA Section: 3 (Biochemical Interactions) Clindamycin [18323-44-9] was the most active of the tested agents against Bacteroides, followed by the nitroimidazole compds. tinidazole [19387-91-8], nimorazole [6506-37-2], and metronidazole [443-48-1]. The min. inhibitory concns. of these drugs were increased by increasing inoculum size, and the min. bactericidal concns. were influenced by the presence of serum. Spectinomycin [1695-77-8] was less active, but was also less affected by inoculum size and serum. It is possible to obtain blood levels of these compds. well above the min. inhibitory concns., suggesting that they may be clin. valuable in the treatment of Bacteroides infections. Mecillinam [32887-01-7], cefazolin [25953-19-9], and cephaloridine [50-59-9] did not appear to have a useful degree of activity. .

Quantification of the effect of anti-anaerobic drugs in experimental Bacteroides fragilis infection in mice

Quantification of the effect of anti-anaerobic drugs in experimental Bacteroides fragilis infection in mice. Dijkmans, B. A. C.; Mattie, H.; Hermans, J.; Van Furth, R. (Dep. Infect. Dis., Univ. Hosp., Leiden 2333 AA, Neth.). J. Antimicrob. Chemother., 13(1), 79-86 (English) 1984. CODEN: JACHDX. ISSN: 0305-7453. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) As a basis for the quantitation of the effect of anti-anaerobic drugs in vivo, an exptl. thigh infection in mice was developed in which co-inoculation of B. fragilis and E. coli is obligatory for proliferation of B. fragilis. The inhibitory effect of metronidazole [443-48-1] and tinidazole [19387-91-8] on the proliferation of B. fragilis was assessed in this model. Both metronidazole and tinidazole showed a significant dose-effect relationship with respect to outgrowth of B. fragilis but not that of E. coli. The effect of both drugs on B. fragilis was similar and at all dosage levels a significant correlation was found between the nos. of B. fragilis and E. coli.