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| CAS No.: | 19387-91-8 |
|---|---|
| Name: | Tinidazole |
| Article Data: | 15 |
| Molecular Structure: | |
|
|
|
| Formula: | C8H13N3O4S |
| Molecular Weight: | 247.275 |
| Synonyms: | Imidazole,1-[2-(ethylsulfonyl)ethyl]-2-methyl-5-nitro- (8CI);1-(Ethylsulfonylethyl)-2-methyl-5-nitroimidazole;Bioshik;CP 12574;Fasigin;Fasigyn;Glongyn;Pletil;Simplotan;Sorquetan;Tini 300; |
| EINECS: | 243-014-4 |
| Density: | 1.43 g/cm3 |
| Melting Point: | 117-121°C(lit.) |
| Boiling Point: | 528.4 °C at 760 mmHg |
| Flash Point: | 273.4 °C |
| Appearance: | solid |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 20/21/22-40 |
| Safety: | 26-36 |
| PSA: | 106.16000 |
| LogP: | 2.13840 |
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1-(2-(ethylthio)ethyl)-2-methyl-5-nitro-1H-imidazole
- 19387-91-8
tinidazole
| Conditions | Yield |
|---|---|
| With oxygen; uranyl(VI) acetate dihydrate In o-xylene; water; acetonitrile at 20℃; under 760.051 Torr; Schlenk technique; Irradiation; | 70% |
| With sodium molybdate; dihydrogen peroxide at 50 - 65℃; Large scale; | 53.9% |
| Conditions | Yield |
|---|---|
| Stage #1: 2,2'-thiobis-ethanol; 2-methyl-5-nitro-1H-imidazole With aluminum (III) chloride In toluene at 45 - 95℃; for 2.5h; Large scale; Stage #2: With sodium molybdate; dihydrogen peroxide In toluene at 45 - 50℃; for 1h; Large scale; | 66.1% |
| Conditions | Yield |
|---|---|
| In ethanol for 4h; Time; Reflux; | 98% |
| In methanol at 60℃; for 6h; | 72% |
- 19387-91-8
tinidazole
- 25459-12-5
1-<2-(ethylsulphonyl)ethyl>-2-methyl-4-nitro-1H-imidazole
| Conditions | Yield |
|---|---|
| With potassium fluoride on basic alumina In 2-ethoxy-ethanol at 120℃; for 0.25h; | 94% |
| With sodium hydrogencarbonate In water for 5h; Heating; ethanol; carbonate, hydroxide, alkoxide; | 91% |
- 10025-99-7
potassium tetrachloroplatinate(II)
- 19387-91-8
tinidazole
- 84431-12-9
(NO2CCHNC(CH3)N(CH2CH2S(O)2C2H5))2PtCl2
| Conditions | Yield |
|---|---|
| In water solid ligand added to aq. soln. of K2(PtCl4), stirred at 50 °C for 1 h; ppt. filtered, washed with EtOH/Et2O, Et2O, dried in vac.; elem. anal.; | 88% |
- 19387-91-8
tinidazole
| Conditions | Yield |
|---|---|
| With hydrogenchloride In methanol | 88% |
| Conditions | Yield |
|---|---|
| In water at 60℃; for 24h; | 87% |
| In water for 1.66667h; |
| Conditions | Yield |
|---|---|
| In ethanol for 4h; Reflux; | 86% |
| Conditions | Yield |
|---|---|
| In ethanol for 4h; Reflux; | 85% |
| Conditions | Yield |
|---|---|
| In ethanol for 4h; Reflux; | 83% |
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Chemistry
Molecular Formula: C8H13N3O4S
Molecular Weight: 247.2715 g/mol
EINECS: 243-014-4
Density: 1.43 g/cm3
Flash Point: 273.4 °C
Melting Point: 125°C to 128 °C
Boiling Point: 528.4 °C at 760 mmHg
Index of Refraction: 1.599
Surface Tension: 57.1 dyne/cm
Enthalpy of Vaporization: 77.31 kJ/mol
Boiling Point: 528.4 °C at 760 mmHg
Vapour Pressure: 1E-10 mmHg at 25 °C
Appearance: almost white or pale yellow, crystalline powder
Solubility: insoluble in water, soluble in acetone and in methylene chloride, sparingly soluble in methanol
Synonyms: Tinidazole ; 1-(2-(ethylsulfonyl)ethyl)-2-methyl-5-nitro-1h-imidazol ; 1-(2-(ethylsulfonyl)ethyl)-2-methyl-5-nitro-imidazol ; 1-(2-(ethylsulfonyl)-ethyl)-2-methyl-5-nitroimidazole ; bioshik ; ethyl(2-(2-methyl-5-nitro-1-imidazolyl)ethyl)sulfone
IUPAC Name of Tinidazole (CAS NO.19387-91-8): 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole hydrochloride
Uses
Tinidazole (CAS NO.19387-91-8) can be used to treat protozoal infections, such as amebiasis, giardiasis, and trichomoniasis.
Toxicity Data With Reference
| 1. | mmo-sat 50 µg/plate | MUREAV Mutation Research. 77 (1980),301. | ||
| 2. | mnt-mus-ipr 50 mg/kg | AIVMBU Archivos de Investigacion Medica. 15 (1984),311. | ||
| 3. | orl-rat LD50:2710 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 11 (1980),811. | ||
| 4. | ipr-rat LD50:2720 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 11 (1980),811. | ||
| 5. | scu-rat LD50:3000 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 11 (1980),811. | ||
| 6. | orl-mus LD50:3200 mg/kg | JMCMAR Journal of Medicinal Chemistry. 21 (1978),781. | ||
| 7. | ipr-mus LD50:2730 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 11 (1980),811. | ||
| 8. | scu-mus LD50:3940 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 11 (1980),811. |
Safety Profile
Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx.
Hazard Codes:
Xn
Risk Statements: 20/21/22-40
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R40:Limited evidence of a carcinogenic effect.
Safety Statements 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: NI6255000
Specification
Tinidazole (CAS NO.19387-91-8), its first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, assure adequate flushing by separating the eyelids with fingers. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product : If swallowed, wash out mouth with water provided person is conscious. Get medical aid immediately.