Detail of "194-59-2"

Reference

Tumor induction by 7H-dibenzo[c,g]carbazole in the respiratory tract of Syrian hamsters

Tumor induction by 7H-dibenzo[c,g]carbazole in the respiratory tract of Syrian hamsters. Sellakumar, Arthur R.; Stenback, Frej; Rowland, Jesudoss; Shubik, Philippe (Inst. Environ. Med., New York Univ. Med. Cent., Tuxedo, N. Y., USA). J. Toxicol. Environ. Health, 3(5-6), 935-9 (English) 1977. CODEN: JTEHD6. ISSN: 0098-4108. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The respiratory tract of male and female Syrian golden hamsters was treated intratracheally with 7H-dibenzo[c,g]carbazole (I) [194-59-2], a tobacco smoke component, by multiple instillations at 2 dose levels. At the lower dose (9 mg), 72% of the animals developed respiratory tract tumors. The group receiving treatment at the higher dose level (30 mg) died earlier because of the toxicity of the compd. In this group, 33% of the animals had respiratory tract tumors. These occurred in the larynx, trachea, bronchi, and lungs, but predominated in the trachea and bronchi. Morphol., most tumors were papillomas and squamous cell carcinomas. This study indicates the highly potent carcinogenic effect of I and that respiratory tumors can be induced in this model system without any carrier dust.

In vitro metabolism of N-methyldibenzo[c,g]carbazole a potent sarcomatogen devoid of hepatotoxic and hepatocarcinogenic properties

In vitro metabolism of N-methyldibenzo[c,g]carbazole a potent sarcomatogen devoid of hepatotoxic and hepatocarcinogenic properties. Perin, F.; Valero, D.; Mispelter, J.; Zajdela, F. (Unite Physiol. Cell., INSERM, Orsay F-91405, Fr.). Chem.-Biol. Interact., 48(3), 281-95 (English) 1984. CODEN: CBINA8. ISSN: 0009-2797. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The metab. of N-methyl-7H-dibenzo[c,g]carbazole (I) [27093-62-5] was investigated in vitro using liver microsomes from 3-methylcholanthrene (MC)-, benzo[c]carbazole (BC)-, and Arochlor-pretreated mice and rats. The EtOAc-extractable metabolites were sepd. by HPLC and most of them were identified by PMR mass spectrometry (MS), and comparison with synthetically prepd. specimens. Mouse and rat microsomes gave rise to the same metabolites. The major metabolites were 5-hydroxy-N-methyl-7H-dibenzo[c,g]carbazole [91000-15-6] (50%), N-hydroxymethyl-7H-dibenzo[c,g]carbazole (II) [91000-16-7] (25-30%), and 3-hydroxy-N-methyl-7H-dibenzo[c,g]carbazole [91000-17-8] (10%). Addn. of 1,1,1-trichloropropene-2,3-oxide to the std. incubation medium permitted inclusion of 2 dihydrodiols among the minor metabolites. No metabolite of 7H-dibenzo[c,g]carbazole (III) [194-59-2] was obsd. after incubation of I, or II, with either mouse or rat microsomes, but the possibility of a slight demethylation cannot be totally excluded. The lack of biotransformation at the N site may explain the lack of hepatotoxicity and liver carcinogenic activity of I. The modulation of metab. by epoxide hydrolase [9048-63-9], cytosol, and glutathione [70-18-8] was also investigated. The results are discussed in light of data previously obtained with hepatotoxic and hepatocarcinogenic III.