Reference

Preparation of L-monovaline ester of ganciclovir purine acyclic nucleosides as virucides

Preparation of L-monovaline ester of ganciclovir purine acyclic nucleosides as virucides.There are some reagents like 194154-40-0 is used in this study. Arzeno, Humberto B.; Beard, Colin C.; Fisher, Lawrence E.; Prince, Anthony (F. Hoffmann-La Roche A.-G., Switz.). PCT Int. Appl. WO 9727194 A1 31 Jul 1997, 32 pp. DESIGNATED STATES: W: AL, AU, BA, BB, BG, BR, CA, CN, CZ, EE, GE, HU, IL, IS, JP, KP, KR, LK, LR, LT, LV, MG, MK, MN, MX, NO, NZ, PL, RO, SG, SI, SK, TR, TT, UA, UZ, VN, AM, AZ, BY, KG, KZ, MD, RU, TJ, TM; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C07D473-00. ICS: C07F007-12; C07F007-10; C07F007-18. APPLICATION: WO 1997-EP228 18 Jan 1997. PRIORITY: US 1996-592104 26 Jan 1996. DOCUMENT TYPE: Patent CA Section: 33 (Carbohydrates) Section cross-reference(s): 34 Process and novel intermediate for prepg. the L-monovaline ester of 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)-methoxy-1,3-propanediol and its pharmaceutically acceptable salts. The present process is a two-step procedure which completely solubilizes the normally insol. ganciclovir, producing a homogeneous soln. which can then undergo selective mono-esterification. The monoester products are of value as antiviral agents (no data) with improved absorption.Except for chemicals metioned above, 194154-40-0 is also used. ..

Preparation of L-monovaline ester of ganciclovir purine acyclic nucleosides as virucides

Preparation of L-monovaline ester of ganciclovir purine acyclic nucleosides as virucides.There are some reagents like 194154-40-0 is used in this study. Arzeno, Humberto B.; Beard, Colin C.; Fisher, Lawrence E.; Prince, Anthony (F. Hoffmann-La Roche A.-G., Switz.). PCT Int. Appl. WO 9727194 A1 31 Jul 1997, 32 pp. DESIGNATED STATES: W: AL, AU, BA, BB, BG, BR, CA, CN, CZ, EE, GE, HU, IL, IS, JP, KP, KR, LK, LR, LT, LV, MG, MK, MN, MX, NO, NZ, PL, RO, SG, SI, SK, TR, TT, UA, UZ, VN, AM, AZ, BY, KG, KZ, MD, RU, TJ, TM; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C07D473-00. ICS: C07F007-12; C07F007-10; C07F007-18. APPLICATION: WO 1997-EP228 18 Jan 1997. PRIORITY: US 1996-592104 26 Jan 1996. DOCUMENT TYPE: Patent CA Section: 33 (Carbohydrates) Section cross-reference(s): 34 Process and novel intermediate for prepg. the L-monovaline ester of 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)-methoxy-1,3-propanediol and its pharmaceutically acceptable salts. The present process is a two-step procedure which completely solubilizes the normally insol. ganciclovir, producing a homogeneous soln. which can then undergo selective mono-esterification. The monoester products are of value as antiviral agents (no data) with improved absorption.Except for chemicals metioned above, 194154-40-0 is also used. ..