Reference

Antitumor pharmaceuticals containing haloalkylureido group-substituted polysilsesquioxanes

Antitumor pharmaceuticals containing haloalkylureido group-substituted polysilsesquioxanes. (Tokuyama Soda Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 58225125 A2 27 Dec 1983 Showa, 13 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C08G077-26. APPLICATION: JP 82-106089 22 Jun 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1, 29 Antitumor pharmaceuticals contain haloalkylureido group-substituted polysilsesquioxanes as active ingredients. Thus, capsules are prepd. 3069-23-6 and 90305-40-1 which are cas registry numbers are also used here. contg. Mg stearate 0.6, lactose 9.5, cryst. cellulose 10 and the polysilsesquioxanes 20 parts. g-(2-Aminoethyl)aminopropyltrimethoxysilane [1760-24-3] in anhyd. hexane was treated with b-chloroethyl isocyanate [1943-83-5] to give a chloroethylureido group-substituted trimethoxysilane [90305-40-1], which was dissolved in MeOH and mixed with H2O, stirred at room temp. for 3 days and worked up to give chloroethylureido-substituted polysilsesquioxanes. These polysilsesquioxanes prolonged survival time when administered i.p. to rats with Walker carcinosarcoma. .

Nitrosoureas as neoplasm inhibitors

Nitrosoureas as neoplasm inhibitors. (Tanabe Seiyaku Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 58201716 A2 24 Nov 1983 Showa, 5 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: A61K031-70. ICA: C07H015-04. APPLICATION: JP 82-85281 19 May 1982. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacology) Section cross-reference(s): 33 The nitrosourea derivs. I (R1 = alkyl; R2 = alkyl or alkoxyalkyl) are neoplasm inhibitors. Thus, 1-(2-chloroethyl)-1-nitroso-3-butyl-3-(Me a-D-glucopyranosid-2-yl)urea (II) [84017-79-8] (1.56 mg/kg/day, i.p., for 5 days), given to mice 24 h after the inoculation of Ehrlich ascites tumor, completely inhibited the tumor growth. II was prepd. by treating Me 2-amino-2-deoxy-a-D-glucopyranoside [4704-14-7] with butylaldehyde [123-72-8], followed by 2-chloroethyl isocyanate [1943-83-5] and N2O4.