Reference

Pharmacology of a new curare-like drug ritetronium

Pharmacology of a new curare-like drug ritetronium. Krasnova, E. I. (Inst. Eksp. Med., Leningrad, USSR). Farmakol. Toksikol. Nov. Prod. Khim. Sint., Mater. Resp. Konf., 3rd, Meeting Date 1974, 107-9. Edited by: Kuz'mitskii, B. B. Beloruss. Med. O-vo. Farmakol. Toksikol.: Minsk, USSR. (Russian) 1975. CODEN: 35ALA9. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacodynamics) The min. myorelaxant dose of ritetronium [62931-17-3] for rabbits (causing a weakening of the neck muscles) was 0.045 mg/kg, i.v., and for cats the min. dose was 0.1 mg/kg. The drug required 25-35 min to reach its full effect. Nivaline [1953-04-4] and proserine [114-80-7] each completely prevented nerve-muscle blockade by ritetronium when given to exptl. animals at 0.1 mg/kg and 4-6 mg/kg, resp. Ritetronium had no blocking effect on the symapthetic or parasympathetic ganglia. It was twice as weak as tubocurarine [57-95-4] in decreasing blood pressure.

Effect of the Bulgarian preparation Nivalin on the bioelectrical activity of the ureters

Effect of the Bulgarian preparation Nivalin on the bioelectrical activity of the ureters. Tsekov, Ts.; Velikov, K.; Kulov, N. (Med. Fak., Med. Akad., Varna, Bulg.). Eksp. Med. Morfol., 16(1), 39-43 (Bulgarian) 1977. CODEN: EKMMA8. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) I.v. injection of 1.5-2 mg Nivalin (I) [1953-04-4]/kg (from Calanthus mivalis) increased the frequency of bioelec. complexes in ureters in 2 waves: within the 1st 15 min after the injection and 60-90 min after the injection. I improved the rhythm of the bioelec. activity. The amplitude gradually increased and was stabilized.