Detail of "19542-77-9"

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Studies on benzyl acetate

Studies on benzyl acetate. II. Use of specific metabolic inhibitors to define the pathway leading to the formation of benzylmercapturic acid in the rat. Chidgey, M. A. 19237-53-7 and 65-85-0 are also occured in this study. J.; Kennedy, J. F.; Caldwell, J. (Med. Sch., St. Mary's Hosp., London W2 1PG, UK). Food Chem. Toxicol., 24(12), 1267-72 (English) 1986. CODEN: FCTOD7. ISSN: 0278-6915. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 17, 62 Specific metabolic inhibitors were used to define the route of metab. of benzyl acetate [140-11-4] leading to the formation of benzylmercapturic acid [19542-77-9]. Male rats were dosed by gavage with [methylene-14C]benzyl acetate (500 mg/kg) alone or together with pyrazole (200 mg/kg), pentachlorophenol (10 mg/kg), or both pentachlorophenol (10 mg/kg) and pyrazole (200 mg/kg), given in each case i.p. Urine and feces were collected and urinary metabolites were assayed by radio-TLC and HPLC. The excretion of 14C was rapid in all cases, with most of the dose excreted in the urine within 24 h. Coadministration of pyrazole (an inhibitor of alc. dehydrogenase [9031-72-5]) with benzyl acetate caused an 11-fold increase in the excretion of benzylmercapturic acid and halved the percentage of the dose excreted as benzoyl glucuronide [19237-53-7]. Pretreatment with pentachlorophenol, an inhibitor of sulfotransferase [9023-09-0] activity in vivo, abolished the excretion of benzylmercapturic acid, whereas excretion of the mercapturate following treatment with both pyrazole and pentachlorophenol was higher than in control or pentachlorophenol-treated rats, but much lower than in the animals given pyrazole alone. Evidently the formation of benzylmercapturic acid involves the sulfate ester of benzyl alc. as an obligatory intermediate and does not appear to involve a metabolic intermediate with sufficient reactivity to have toxicol. relevance. .

Studies on benzyl acetate

Studies on benzyl acetate. I. Effect of dose size and vehicle on the plasma pharmacokinetics and metabolism of [methylene-14C]benzyl acetate in the rat. Chidgey, M. A. J.; Caldwell, J. (Med. Sch., St. Mary's Hosp., London W2 1PG, UK). Food Chem. Toxicol., 24(12), 1257-65 (English) 1986. CODEN: FCTOD7. ISSN: 0278-6915. DOCUMENT TYPE: Journal CA Section: 62 (Essential Oils and Cosmetics) Section cross-reference(s): 1, 4, 17 Male Fischer 344 rats received (methylene-14C]benzyl acetate (I) [140-11-4] by gavage in a dose of 5, 250 or 500 mg/kg, as the neat substance, in corn oil or in propylene glycol. Urine and feces were collected and urinary metabolites were assayed by radio-TLC and HPLC. Other animals were killed at various times and exsanguinated, and plasma levels of 14C in plasma occurred earliest and were highest when I was given neat. Peak levels were lower and absorption was delayed with the propylene glycol [57-55-6] vehicle. The use of corn oil as the dose vehicle at the higher doses (250 and 500 mg/kg) led to the maintenance of plateau plasma levels, at about one half of the peak levels seen with the neat compd., for up to 8 h after administration. At the 5 mg/kg dose, the plasma levels of 14C were essentially the same whether the dose was given in corn oil or propylene glycol. At the 250- and 500-mg/kg doses, at all time points, the major metabolite in plasma was benzoic acid [65-85-0], accompanied by smaller amts. of hippuric acid [495-69-2],. Benzyl alc. [100-51-6] was also detected in some plasma samples. At the 5-mg/kg dose, the major plasma metabolite was hippuric acid, together with a smaller amt. of benzoic acid. When propylene glycol was used as the vehicle at this dose level, benzylmercapturic acid [19542-77-9] was also present in the plasma. The major urinary metabolite was hippuric acid (66% of the dose), with benzoic acid (2%) and benzylmercapturic acid (1%) also present. The elimination of benzoyl glucuronide [19237-53-7] increased with increasing dose, from 3 to 11% of the dose.