Detail of "19545-26-7"

Reference

Multicomponent reactions in organic synthesis: an approach to viridin and viridin analogs

Multicomponent reactions in organic synthesis: an approach to viridin and viridin analogs. Robotham, Claude Vincent (Univ. of Florida, Gainesville, FL, USA).There are some reagents with their cas registry numbers 3306-52-3 and 19545-26-7 are used in this study. 146 pp. Avail. UMI, Order No. DA3105660 From: Diss. Abstr. Int., B 2004, 64(9), 4360 (English) 2003. DOCUMENT TYPE: Dissertation CA Section: 21 (General Organic Chemistry) Section cross-reference(s): 9, 32, 35 Abstract Unavailable .

Nuclear translocation of PKCz during ischemia and its inhibition by wortmannin, an inhibitor of phosphatidylinositol 3-kinase

Nuclear translocation of PKCz during ischemia and its inhibition by wortmannin, an inhibitor of phosphatidylinositol 3-kinase. Mizukami, Yoichi; Hirata, Takao; Yoshida, Ken-ichi (Department of Legal Medicine, Yamaguchi University School of Medicine, 1144 Kogushi, Ube 755, Japan).In this study， 19545-26-7 and 141436-78-4 are also used. FEBS Letters, 401(2,3), 247-251 (English) 1997 Elsevier. CODEN: FEBLAL. ISSN: 0014-5793. DOCUMENT TYPE: Journal CA Section: 14 (Mammalian Pathological Biochemistry) Section cross-reference(s): 1 Protein kinase Cz (PKCz), a member of the atypical PKC subgroup, is insensitive to Ca2+, diacylglycerol, and phorbol esters, but is activated by phospholipids such as phosphatidylinositol-3,4,5-triphosphate, a product of phosphatidylinositol 3-kinase (PI3-kinase). Here the authors show that PKCz translocates from the cytosol to the 1000 ′ g pellet (nuclear-myofibrillar) fraction during ischemia for 40 min in Langendorff-perfused rat hearts. In addn., immunohistochem. observation shows that ischemia induces the translocation of PKCz to the nucleus. The nuclear translocation during ischemia is inhibited in a dose-dependent manner by wortmannin (10-9-10-7 M), an inhibitor of PI3-kinase. .