Detail of "19598-90-4"

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Gadolinium-Based Hybrid Nanoparticles as a Positive MR Contrast Agent

All Rights Reserved. Gadolinium-Based Hybrid Nanoparticles as a Positive MR Contrast Agent. Hifumi, Hiroki; Yamaoka, Seiichi; Tanimoto, Akihiro; Citterio, Daniel; Suzuki, Koji (Department of Applied Chemistry, Faculty of Science and Technology and Department of Diagnostic Radiology, School of Medicine, Keio University 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan). Journal of the American Chemical Society, 128(47), 15090-15091 (English) 2006 American Chemical Society. CODEN: JACSAT. ISSN: 0002-7863.Some commonly used reagents like 19598-90-4 and 7783-28-0 are used in this experiment. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 8, 9, 77 A new nanoparticulate inorg.-org. hybrid-type pos. contrast agent (CA), PGP/dextran-K01, was synthesized based on a GdPO4 inorg. core as a relaxation-time-shortening moiety and a dextran-coating, which generates monodispersibility in water, a high relaxation-time-shortening effect by retaining a large no. of water mols. in proximity of the core and toxicity redn. in in-vivo studies. This PGP/dextran-K01 nanoparticle has high r1 and r2 values and a significantly low r2/r1 value, 1.1, which is unprecedented and which is the lowest value among existing nanoparticulate CAs indicating that PGP/dextran-K01 is a pos. contrast agent. Because of this low r2/r1 value and the nanoparticulate shape, PGP/dextran-K01 will be a useful clin. substitute for neg. CAs based on iron oxides. .