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CAS No.: | 19798-80-2 |
---|---|
Name: | 2-Amino-4-chloropyridine |
Article Data: | 32 |
Molecular Structure: | |
Formula: | C5H5ClN2 |
Molecular Weight: | 128.561 |
Synonyms: | 4-chloro-1H-pyridin-2-amine;4-Chloro-pyridin-2-ylamine;4-chloro-2-aminopyridine;4-chloropyridin-2-amine;4-Chloro-2-amine-pyridine;2-Amino-4-chloro pyridine/2-Amino-6-chloro pyridine;4-Chloro-2-amine-pyridin; |
EINECS: | -0 |
Density: | 1.327 g/cm3 |
Melting Point: | 126-127 °C |
Boiling Point: | 240.793 °C at 760 mmHg |
Flash Point: | 99.428 °C |
Appearance: | light yellow cryst |
Hazard Symbols: | Xi,Xn |
Risk Codes: | 22-36/37/38 |
Safety: | 26 |
PSA: | 38.91000 |
LogP: | 1.89840 |
tert-butyl (4-chloropyridin-2-yl) carbamate
2-Amino-4-chloropyridine
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane at 20℃; for 18h; | 100% |
With hydrogenchloride In 1,4-dioxane at 20℃; for 18h; | 99% |
With trifluoroacetic acid In dichloromethane at 20℃; | 90% |
With hydrogen bromide for 2h; | 87% |
With hydrogen bromide for 2h; Ambient temperature; |
2,2-dimethyl-3-(4-chloropyrid-2-yl)-4-oxo-4H-1,3-benzoxazine
2-Amino-4-chloropyridine
Conditions | Yield |
---|---|
With hydrogenchloride for 8h; Heating; | 95% |
With hydrogenchloride Hydrolysis; |
4-chloropicolinamide
2-Amino-4-chloropyridine
Conditions | Yield |
---|---|
With bromine; potassium hydroxide In water at 90℃; for 2h; Cooling with ice; | 84% |
With calcium hypochlorite In water at 60 - 80℃; Temperature; | 81% |
With sodium hydroxide; bromine In water at 80℃; for 1.5h; Hofmann Degradation; | 64% |
2-Amino-4-chloropyridine
Conditions | Yield |
---|---|
With hydrazine hydrate; sodium nitrite In hydrogenchloride; methanol; water; acetic acid | 44% |
With hydrazine hydrate; acetic acid; sodium nitrite In hydrogenchloride; methanol; water | 37 g (60%) |
2,4-dichloropyridine
A
2-Amino-4-chloropyridine
B
4-Amino-2-chloropyridine
Conditions | Yield |
---|---|
With ammonium hydroxide at 170 - 180℃; | |
With ammonium hydroxide at 180℃; |
4-chloro-pyridine-2-carbonyl azide
2-Amino-4-chloropyridine
Conditions | Yield |
---|---|
With acetic acid |
A
2-Amino-4-chloropyridine
Conditions | Yield |
---|---|
With hydrogenchloride at 60℃; for 3h; | A 70 mg B 45 mg |
4-chloro-2-pyridinylisocyanate
2-Amino-4-chloropyridine
Conditions | Yield |
---|---|
With hydrogenchloride for 48h; Heating; Yield given; |
4-chloropyridine-2-carbohydrazide
2-Amino-4-chloropyridine
Conditions | Yield |
---|---|
With hydrogenchloride; acetic acid; sodium nitrite 1.) water, 15 min, 2.) water, heating; Yield given. Multistep reaction; |
2,4-dichloropyridine
A
2-Amino-4-chloropyridine
B
4-Amino-2-chloropyridine
Conditions | Yield |
---|---|
at 180℃; |
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The 4-Chloro-pyridin-2-ylamine is an organic compound with the formula C5H5ClN2. The IUPAC name of this chemical is 4-chloropyridin-2-amine. With the CAS registry number 19798-80-2, it is also named as 2-Pyridinamine, 4-chloro-. The product's categories are Pyridine; Blocks; Pyridines; Amines and Anilines; Heterocycles; Pyridines, Pyrimidines, Purines and Pteredines; Heterocyclic Series; Pharmacetical; Pyridine Series; Amines; Nucleotides and Nucleosides; Bases & Related Reagents; Nucleotides; Pharmaceutical Intermediate; Amino-Pyridine Eeries.
Physical properties about 4-Chloro-pyridin-2-ylamine are: (1)ACD/LogP: 1.32; (2)ACD/LogD (pH 5.5): 0.897; (3)ACD/LogD (pH 7.4): 1.308; (4)ACD/BCF (pH 5.5): 2.244; (5)ACD/BCF (pH 7.4): 5.785; (6)ACD/KOC (pH 5.5): 47.149; (7)ACD/KOC (pH 7.4): 121.544; (8)#H bond acceptors: 2; (9)#H bond donors: 2; (10)Polar Surface Area: 38.91 Å2; (11)Index of Refraction: 1.607; (12)Molar Refractivity: 33.475 cm3; (13)Molar Volume: 96.888 cm3; (14)Polarizability: 13.271×10-24cm3; (15)Surface Tension: 54.396 dyne/cm; (16)Density: 1.327 g/cm3; (17)Flash Point: 99.428 °C; (18)Enthalpy of Vaporization: 47.772 kJ/mol; (19)Boiling Point: 240.793 °C at 760 mmHg; (20)Vapour Pressure: 0.037 mmHg at 25°C.
Preparation: this chemical can be prepared by t-butyl N-(4-chloro-2-pyridinyl)carbamate. This reaction will need reagent 25 percent HBr. The reaction time is 2 hours. The yield is about 87%.
Uses of 4-Chloro-pyridin-2-ylamine: it can be used to produce 4-methoxy-pyridin-2-ylamine at temperature of 140 °C. It will need solvent methanol with reaction time of 7 hours. The yield is about 44%.
When you are using this chemical, please be cautious about it as the following:
It is harmful if swallowed. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, this chemical is irritating to eyes, respiratory system and skin.
You can still convert the following datas into molecular structure:
(1)SMILES: c1cnc(cc1Cl)N
(2)InChI: InChI=1/C5H5ClN2/c6-4-1-2-8-5(7)3-4/h1-3H,(H2,7,8)
(3)InChIKey: RQMWVVBHJMUJNZ-UHFFFAOYAQ
(4)Std. InChI: InChI=1S/C5H5ClN2/c6-4-1-2-8-5(7)3-4/h1-3H,(H2,7,8)
(5)Std. InChIKey: RQMWVVBHJMUJNZ-UHFFFAOYSA-N