Detail of "19877-89-5"

Reference

Effects of Vincanol on the uptake of catechol amines (CA) by rat brain synaptosomes

Effects of Vincanol on the uptake of catechol amines (CA) by rat brain synaptosomes. Majsa, Z. (Pharmacol. Lab., Gedeon Richter, Ltd. 51-61-6 and 120-80-9 are also occured in this study., Budapest, Hung.). Proc. Hung. Annu. Meet. Biochem., 16th, 101-2. Edited by: Rosdy, B. Biochem. Sect. Hung. Chem. Soc.: Budapest, Hung. (English) 1976. CODEN: 34IRAQ. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacodynamics) The in vitro uptake of noradrenaline [51-41-2] by synaptosomes of rat whole brain was inhibited in decreasing order of potency by d-amphetamine [51-64-9], desipramine [50-47-5], vincanol (I) [19877-89-5], and amantadine [768-94-5]. The order of potency in inhibiting dopamine [51-61-6] uptake was d-amphetamine, I, and amantadine; desipramine not being tested. It is suggested that I has some antiparkonsonism and antidepressant activity. .

Biochemical effects of semisynthetic vinca alkaloids on the central nervous system

Biochemical effects of semisynthetic vinca alkaloids on the central nervous system. Rosdy, B.; Szporny, L. (Pharmacol. Lab., Chem. Works Gedeon Richter Ltd., Budapest, Hung.). Congr. Hung. Pharmacol. Soc., [Proc.], Volume Date 1974, 2(5, Symp. Pharmacol. Vinca Alkaloids), 77-80 (English) 1976. CODEN: CPSPDT. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Apovincaminic acid Et ester [42971-09-5] (50 mg/kg, i.p.) decreased noradrenaline [51-41-2] and 5-hydroxytryptamine [50-67-9] levels in rat brain. Vincanol (I) [19877-89-5] produced a dose-related increase in 5-hydroxytryptamine-like fluorescence in brain and liver and decreased brain noradrenaline. Reserpine-depletion of noradrenaline and dopamine was frequently potentiated by I, whereas the I-induced increase in fluorescence was not depleted by reserpine or tetrabenazine. Ninhydrin and o-phthaldialdehyde derived fluorescence were not influenced by I. Thus, I causes the formation of a new endogenous or exogenous fluorescent metabolite, which appears to be formed in the liver and transported to the brain.