Detail of "19879-84-6"

Reference

Cellular interactions of auranofin and a related gold complex with RAW 264

Cellular interactions of auranofin and a related gold complex with RAW 264.7 macrophages. Snyder, Rosanne M.; Mirabelli, Christopher K.; Crooke, Stanley T. (Dep. Mol. Pharmacol., Smith Kline and French Lab., Philadelphia, PA 19101, USA). Biochem. Pharmacol., 36(5), 647-54 (English) 1987. CODEN: BCPCA6. ISSN: 0006-2952. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effects of auranofin (AF) [34031-32-8] and triethylphosphine gold chloride (TEPG) [15529-90-5] on macrophage-like RAW 264.7 cells were studied. More gold from TEPG than AF assocd. with cells over time and at a variety of concns. The cellular assocn. of AF and TEPG was temp. dependent; the energy of activation for cell assocn., the rate-limiting step in the thiol exchange process, was lower for TEPG than AF. Cellular assocn. and uptake of both compds. did not require metabolic energy. Efflux of both AF and TEPG was time-, temp.In this experiment, several chemicals are used like 70-18-8 and 7440-57-5 -, and thiol-dependent. Sequential thiol exchange may be a generic phenomenon for cellular uptake and distribution of thiol reactive gold compds. and the rate-limiting step is the exchange of either tetraacetylthioglucose [19879-84-6] or chloride for a membrane-localized sulfhydryl group. .

2,3,4,6-tetra-O-acetyl-1-thio-b-D-glucopyranose as detoxication agent

2,3,4,6-tetra-O-acetyl-1-thio-b-D-glucopyranose as detoxication agent. Suzuki, Shuichi; Sato, Toshio; Imai, Zenjiro; Harada, Michio; Miyachi, Yutaro; Yoshioka, Yoshiatsu (Nippon Chemiphar Co., Ltd., Japan). Japan. JP 52031846 B4 17 Aug 1977 Showa, 2 pp. (Japanese). (Japan). CODEN: JAXXAD. CLASS: IC: C07H013-06. APPLICATION: JP 69-65334 20 Aug 1969. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 4, 33 The detoxication agent 2,3,4,6-tetra-O-acetyl-1-thio-b-D--glucopyranose (I) [19879-84-6] is prepd. by treatment of II [47537-23-5] with basic ion-exchange resins. Thus, b-D-glucopyranose [492-61-5] was treated with anhyd. HOAc to form 1,2,3,4,6-penta-O-acetyl-b-D-glucopyranose [604-69-3], which was treated with Br to give 1-bromo-2,3,4,6-tetra-O-acetyl-b-glucopyranose (III) [6919-96-6]. III dissolved in Me2CO was treated with pseudothiourea [17356-08-0] to produce II. II dissolved in MeOH was mixed with Amberlite IRA 411 at 40° for 3 h to give I.