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CAS No.: | 1989-33-9 |
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Name: | 9-Carboxyfluorene |
Article Data: | 91 |
Molecular Structure: | |
Formula: | C14H10O2 |
Molecular Weight: | 210.232 |
Synonyms: | Fluorene-9-carboxylicacid (6CI,7CI,8CI);9H-Fluorene-9-carboxylicacid;NSC 5322; |
EINECS: | 217-866-2 |
Density: | 1.309 g/cm3 |
Melting Point: | 228-231 °C(lit.) |
Boiling Point: | 314.9 °C at 760 mmHg |
Flash Point: | 158.4 °C |
Solubility: | insoluble in water |
Appearance: | white to yellow crystalline powder |
Hazard Symbols: | Xi |
Risk Codes: | 36/37/38 |
Safety: | 22-24/25-36/37/39-27-26 |
PSA: | 37.30000 |
LogP: | 2.88350 |
Conditions | Yield |
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With n-butyllithium In tetrahydrofuran; hexane; toluene | 87% |
Conditions | Yield |
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With 18-crown-6 ether; potassium carbonate In dimethyl sulfoxide under 760 Torr; for 2h; Product distribution; Ambient temperature; other methylene active compounds; var. crown ethers; var. alkali carbonates; var. solvents; | 82% |
With 18-crown-6 ether; potassium carbonate In dimethyl sulfoxide under 760 Torr; for 2h; Ambient temperature; | 82% |
With potassium carbonate; Acetanilid In dimethyl sulfoxide at 20℃; for 4h; | 48% |
Conditions | Yield |
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With samarium; chloro-trimethyl-silane; tetra-(n-butyl)ammonium iodide In acetonitrile at 20℃; under 760.051 Torr; for 2h; Electrochemical reaction; Cooling with ice; | 81% |
Conditions | Yield |
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With hydrogenchloride; nitrogen; acetic acid In water; toluene | 80.7% |
With hydrogenchloride; potassium ethoxide In water | 72.7% |
Stage #1: 9H-fluorene With sodium hydride In toluene at 125℃; for 4h; Inert atmosphere; Reflux; Stage #2: Diethyl carbonate In toluene at 90℃; for 4.5h; Stage #3: With hydrogenchloride; water In toluene at 20 - 40℃; | 10 g |
Stage #1: 9H-fluorene With sodium hydride In toluene at 125℃; for 4h; Inert atmosphere; Stage #2: Diethyl carbonate In toluene at 90℃; for 4.5h; Inert atmosphere; Stage #3: With hydrogenchloride; acetic acid In water; toluene Reflux; | 10 g |
10-diazophenanthren-9(10H)-one
A
9H-fluorene-9-carboxylic acid
B
9,10-phenanthrenequinone
Conditions | Yield |
---|---|
In perchloric acid Irradiation; | A 80% B 15% |
In sodium hydroxide Irradiation; | A 53% B 20% |
9-trimethylsilyloxy-9H-fluorene-9-carbonitrile
9H-fluorene-9-carboxylic acid
Conditions | Yield |
---|---|
With hydrogenchloride; acetic acid; tin(ll) chloride Heating; | 74% |
Benzilic acid
A
9H-fluorene-9-carboxylic acid
B
3,3,6,6-tetraphenyl-2,5-p-dioxanedione
Conditions | Yield |
---|---|
With sulfuric acid In chloroform Ambient temperature; | A 73% B 11% |
Conditions | Yield |
---|---|
69% | |
Multi-step reaction with 3 steps 1: potassium ethylate; methanol 2: acetic acid; sulfuric acid; water 3: acetic acid; aqueous hydrogen peroxide View Scheme | |
Multi-step reaction with 2 steps 1: diethyl ether View Scheme | |
Multi-step reaction with 2 steps 1: nBuLi 2: (i) nBuLi, THF, hexane, (ii) /BRN= 1900390/ View Scheme |
Conditions | Yield |
---|---|
trifluorormethanesulfonic acid In benzene at -45℃; for 1h; | 65% |
With aluminium trichloride; benzene zuletzt bei Siedetemperatur; | |
With sulfuric acid In acetic acid |
Conditions | Yield |
---|---|
With bis(tricyclohexylphosphine)nickel(II) dichloride; tetra-(n-butyl)ammonium iodide; zinc In N,N-dimethyl acetamide at 20℃; under 760.051 Torr; Schlenk technique; | 62% |
The IUPAC name of this chemical is 9H-fluorene-9-carboxylic acid. With the CAS registry number 1989-33-9 and EINECS 217-866-2, it is also named as 9-Carboxyfluorene. The product's categories are Fluorene Derivatives; Benzocycles; Fluorenes, Flurenones; Organic Acids; Fluorenes; Fluorenes & Fluorenones; C13 to C42+; Carbonyl Compounds; Carboxylic Acids. It is white to yellow crystalline powder which should be sealed in the container and stored in the cool and dry place. What's more, people should ensure that the workplace has well-ventilated equipment.
The other characteristics of this product can be summarized as: (1)ACD/LogP: 2.68; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.87; (4)ACD/LogD (pH 7.4): -0.75; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 10.52; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 26.3 Å2; (13)Index of Refraction: 1.668; (14)Molar Refractivity: 59.9 cm3; (15)Molar Volume: 160.5 cm3; (16)Polarizability: 23.74×10-24 cm3; (17)Surface Tension: 58.7 dyne/cm; (18)Density: 1.309 g/cm3; (19)Flash Point: 158.4 °C; (20)Enthalpy of Vaporization: 58.71 kJ/mol; (21)Boiling Point: 314.9 °C at 760 mmHg; (22)Vapour Pressure: 0.000192 mmHg at 25°C.
Preparation of 9H-Fluorene-9-carboxylic acid: It can be obtained by fluorene and carbon dioxide. This reaction needs reagent 18-crown-6, potassium carbonate and solvent dimethylsulfoxide at ambient temperature and pressure of 760.0002. The reaction time is 2 hours. The yield is 82%.
Uses of 9H-Fluorene-9-carboxylic acid: It is used in organic synthesis and as raw material of dyes, resins and pesticides. What's more, it can react with benzene to get fluoren-9-yl-phenyl ketone. This reaction needs catalytic agent TFSA at temperature of 63 °C. The reaction time is 4 hours. The yield is 60%.
When you are using this chemical, please be cautious about it as the following:
It is irritating to eyes, respiratory system and skin, so people should not breathe dust and avoid contact with skin and eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. After using this chemical, take off immediately all contaminated clothing. If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection.
People can use the following data to convert to the molecule structure.
1. SMILES:O=C(O)C3c1ccccc1c2c3cccc2
2. InChI:InChI=1/C14H10O2/c15-14(16)13-11-7-3-1-5-9(11)10-6-2-4-8-12(10)13/h1-8,13H,(H,15,16)
3. InChIKey:DNVJGJUGFFYUPT-UHFFFAOYAY