Detail of "19910-33-9"

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CAS Number:
19910-33-9
Name:
Benzeneacetic acid, a-methyl-4-nitro-
Molecular Structure:
Formula:
C₉H₉NO₄
Molecular Weight:
195.17
Synonyms:
Hydratropicacid, p-nitro- (6CI,7CI,8CI);(α)-2-(4-Nitrophenyl)propionic acid;2-(4-Nitrophenyl)propanoic acid;2-(4-Nitrophenyl)propionic acid;2-(p-Nitrophenyl)propionic acid;α-Methyl-4-nitrobenzeneacetic acid;
Density:
1.337 g/cm³
Melting Point:
88-89 °C
Boiling Point:
361.9 °C at 760 mmHg
Flash Point:
160.5 °C
Hazard Symbols:
Xi
Risk Codes:
36/37/38
Safety:
26-37/39 Details

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Pyrimido[2,1-b]benzothiazole-8-acetic acid derivatives as allergy inhibitors and antiasthmatics: Pyrimido[2,1-b]benzothiazole-8-acetic acid derivatives as allergy inhibitors and antiasthmatics. Rowlands, David Alun; Matharu, Saroop Singh; Hairsine, Peter Wilfred (Roussel Laboratories Ltd., UK). Brit. UK Pat. Appl. GB 2178429 A1 11 Feb 1987, 12 pp. (United Kingdom) CODEN: BAXXDU. CLASS: ICM: C07D513-04. ICS: A61K031-505. APPLICATION: GB 86-18641 30 Jul 1986. PRIORITY: GB 85-19261 31 Jul 1985. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 The title compds. [I; R, R3 = H, alkyl; RR3C = cycloalkyl; R1 = alkoxy; R2 = H, alkyl, alkoxycarbonyl, (substituted) aryl, heteroaryl] were prepd. as allergy inhibitors. 4-O2NC6H4CH2CHMeCO2H was converted to its acid chloride using SOCl2 in toluene and this was reacted with 1-adamantanol to give a (nitrophenyl)propionate ester which was reduced to 1-adamantyl-2-(p-aminophenyl)propionate by hydrogenation in EtOH over Pd/C. 19910-33-9 and 590-67-0 which are cas registry numbers of substances are two of reagents here. This was cyclocondensed with KSCN in the presence of Br using AcOH as solvent at 50°. The resulting 1-adamantyl-2-amino-a-methylbenzothiazole-6-acetate was heated neat with PhCYCCO2Et to give I (R = H, R1 = 1-adamantyl, R2 = Ph, R3 = Me) (II). II inhibited antigen-induced bronchoconstriction in guinea pig lung with an IC50 of ￡1 mM. .

Pyrimido[2,1-b]benzothiazole derivatives: Pyrimido[2,1-b]benzothiazole derivatives. (Roussel-UCLAF, UK). Jpn. Kokai Tokkyo Koho JP 62029592 A2 7 Feb 1987 Showa, 9 pp. 107746-64-5 and 19910-33-9 are also occured in this study. (Japan) CODEN: JKXXAF. CLASS: ICM: C07D513-04. ICS: A61K031-495. APPLICATION: JP 86-171948 23 Jul 1986. PRIORITY: GB 85-19261 31 Jul 1985. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1, 63 The title compds. [I; R, R3 = C1-6 alkyl, C3-6 cycloalkyl; R1 = C7-12 (cyclo)alkyl(oxy); R2 = H, C1-6 alkyl, C2-7 alkoxycarbonyl, C3-6 cycloalkyl, aralkyl, (substituted)aryl, heteroaryl] and acid addn. salts, useful as allergy inhibitors, were prepd. by cyclocondensation of benzothiazole derivs. (II; R4 = OH, C1-6 alkoxy) with R2CYCCO2R5 (R5 = alkyl) followed by transesterification with alcs. R1H in the presence of Pd. A mixt. of II (R = H, R3 = Me, R4 = 1-methylcyclohexyloxy) and PhCYCCO2Et was heated at 160° for 0.5 h to give 41% I (R = H, R1 = 1-methylcyclohexyloxy, R2 = Ph, R3 = Me). This at 1-10 mM in vivo inhibited by 50% ovalbumin-induced bronchial structure in Porcellus sensitized with ovalbumin. .