Detail of "19926-22-8"

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Effects of 7,8-benzoflavone on skin tumor-initiating activities of various 7- and 12-substituted derivatives of 7,12-dimenthylbenz[a]anthracene in mice

Effects of 7,8-benzoflavone on skin tumor-initiating activities of various 7- and 12-substituted derivatives of 7,12-dimenthylbenz[a]anthracene in mice. DiGiovanni, J.; Slaga, T. J.; Viaje, A.; Berry, D. L.; Harvey, R. G.; Juchau, M. R. (Dep. Pharmacol., Univ. Washington Sch. Med., Seattle, Wash., USA). J. Natl. Cancer Inst., 61(1), 135-40 (English) 1978. CODEN: JNCIAM. ISSN: 0027-8874. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The skin tumor-initiating activities of various 7- and 12-substituted derivs. of 7,12-dimethylbenz[a]anthracene (I) [57-97-6] were investigated in female outbred Charles River CD-1 mice. 7-Formyl-12-methylbenz[a]anthracene (7-CHO-12-MBA) [13345-61-4] at 740 nmol/mouse was an effective tumor initiator, at a dose 74-fold greater than that of I. 7,8-Benzoflavone (7,8-BF) [604-59-1] inhibited the tumor-initiating activity of 7-CHO-12-MBA by 51%. 12-Formyl-7-methylbenz[a]anthracene [17513-40-5] and 7,12-diformylbenz[a]anthracene [19926-22-8], applied at initiatingh doses of 740 and 704 nmol/mouse, resp., were much less active than 7-CHO-12-MBA. 7-Bromomethyl-12-methylbenz[a]anthracene (7-BRME-12-MBA) [16238-56-5] and 7-bromomethylbenz[a]anthracene (7-BRMEBA) [24961-39-5] were also investigated. 7-BRME-12-MBA was a more effective tumor initiator than 7-BRMEBA, but both were less active than I. 7,8-BF inhibited the tumor-initiating activity of 7-BRME-12-MBA and 7-BRMEBA by 34 and 54%, resp. 12-Bromomethyl-7-methylbenz[a]anthracene (12-BRME-7-MBA) [59230-81-8] was as active an initiator as 7-BRME-12-MBA. 7,8-BF inhibited tumor initiation with 12-BRME-7-MBA by 29%. Three naturally occurring flavones, quercetin [117-39-5], myricetin [529-44-2], and 4',5,7-trihydroxyflavonone [480-41-1], and the cytochrome P450, inhibitor 1-benzylimidazole [4238-71-5] were investigated after topical application (100 mg) for their effects on tumor initiation with I. Quercetin inhibited tumor initiation with I by 22%, whereas myricetin and 4',5,7-trihydroxyflavanone enhanced tumor initiation with I by 54 and 29%, resp. 1-Benzylimidazole had no effect. The abilities of the flavones and 1-benzylimidazole to inhibit aryl hydrocarbon hydroxylase [9037-52-9] in vitro did not correlate with their effects on tumor initiation with I.