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Reference

Residue analyses on 2-amino-4-phenylthiazole, a piscine anesthetic, in fishes - III

Residue analyses on 2-amino-4-phenylthiazole, a piscine anesthetic, in fishes - III. Metabolism in rainbow trout and carp. Suzuki, Akira; Shimura, Masaru; Kikuchi, Takahiko; Sekizawa, Yasuharu (Res. Lab., Meiji Seika Kaisha, Ltd., Yokohama, Japan). Nippon Suisan Gakkaishi, 43(7), 837-47 (English) 1977. CODEN: NSUGAF. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The major biotransformation product of 2-amino-4-phenylthiazole (I) [2010-06-2] in rainbow trout (Salmo gairdneri irideus) was isolated from water following exposure of fish to the anesthetic. The isolated cryst. metabolite was shown by means of UV, IR, and optical rotatory dispersion spectroscopy and gas chromatog. to be identical to 2-amino-4-phenylthiazole-2-N-.beta.-mono-D-glucopyranosiduronic acid (II) [56316-58-6], the major biotransformation product previously found in medaka (killifish, Oryzias latipes). The major biotransformation product in carp (Cyprinus carpio) was also identified as II, by mol. sieve, thin layer and gas chromatog. Conversion of I to the N-glucuronyl conjugate was 8 and 12%, resp., in rainbow trout and carp as shown by thin layer chromatog of exts. from fish treated with 3H-labeled anesthetic. In addn., a minor metabolite of the anesthetic in rainbow trout was isolated as a yellowish-white cryst. powder and identified as 2-acetamido-4-(4'-hydroxyphenyl)thiazole [64309-02-0] by means of UV and IR spectroscopy, NMR, and mass spectrometry. Chromatog. suggested that this same metabolite was also formed in carp but in concns. too low for isolation and definitive identification.

Disazo dyes

Disazo dyes. Vor der Brueck, Dieter; Wolfrum, Gerhard (Bayer A.-G., Ger.). Ger. Offen.Except for chemicals metioned above, 6375-02-6 is also used. DE 2557410 30 Jun 1977, 56 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C09B031-14. APPLICATION: DE 75-2557410 19 Dec 1975. DOCUMENT TYPE: Patent CA Section: 40 (Dyes, Fluorescent Whitening Agents, and Photosensitizers) Disazo dyes (I, R = Cl, EtO; R1 = Cl, SO3H; R2 = Et, CH2CH2CN; R3 = CH2CH2Ph, 3-HO3SC6H4CH2) are prepd. and used to dye polyamide fibers fast, greenish navy blue shades. Thus, 4,3-EtO(HO3S)C6H3NH2 [6375-02-6] was diazotized, coupled with 2-amino-4-phenylthiazole [2010-06-2], the resulting azo compd. [63817-47-0] isolated, diazotized, and coupled with 3-MeC6H4N(CH2CH2CN)CH2CH2Ph [63817-48-1] to give I(R = EtO, R1 = 3-SO3H, R2 = CH2CH2CN, R3 = CH2CH2Ph) [63817-49-2]. The other I are similarly prepd. .