Detail of "2011-67-8"

CAS Number:
2011-67-8
Name:
1,3-Dihydro-1-methyl-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one
Superlist Name:
Nimetazepam
Molecular Structure:
Formula:
C₁₆H₁₃N₃O₃
Molecular Weight:
295.30
Synonyms:
1-Methyl-5-phenyl-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one;1-Methylnitrazepam;Elimin;Erimin;Hypnon;Methylnitrazepam;N-Methylmogadon;N-Methylnitrazepam;Nimetazam;Nimetazepam;Ro 5-3453;S 1530;2H-1,4-Benzodiazepin-2-one,1,3-dihydro-1-methyl-7-nitro-5-phenyl-;
EINECS:
217-931-5
Density:
1.331 g/cm³
Boiling Point:
540.467 °C at 760 mmHg
Flash Point:
280.665 °C

Please post your buying leads,so that our qualified suppliers will soon contact you!
*Required Fields

Enzymic dealkylation of a substituted aminoacetamidobenzophenone and cyclization to the corresponding benzodiazepine in vitro: Enzymic dealkylation of a substituted aminoacetamidobenzophenone and cyclization to the corresponding benzodiazepine in vitro. Illing, H. P. A.; Yeomans, M. A.; Rising, P. A.; Johnson, P. (Drug Dev., Hoechst Pharm. Res. Lab., Milton Keynes, Engl.). Xenobiotica, 7(7), 439-54 (English) 1977. CODEN: XENOBH. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) In dog and mouse liver slices labeled C 720045 (I) [59049-59-1] was metabolized to nitrazepam (II) [146-22-5] and nimetazepam (III) [2011-67-8] but in rat liver slices more polar products were formed. In microsomal prepns. from all species, with an NADP-regenerating system, 2 products were formed simultaneously, one of which was further metabolized to III. HCHO was produced concomitantly with the formation of one initial metabolite and concomitantly with the metab. of the second initial metabolite to III. The enzyme required to initiate the metab. of I was located in the microsomal fraction, required NADPH and air, was induced 2-fold by pretreatment with phenobarbitone, and was inhibited by CO, SKF 525A, and 8-hydroxyquinoline but not by iproniazid or cysteine. III was formed from I by dealkylation and cyclizaton via a specific intermediate metabolite.

The metabolism of a substituted aminoacetamidobenzophenone and cyclization to the corresponding benzodiazepine in the rat in vivo: The metabolism of a substituted aminoacetamidobenzophenone and cyclization to the corresponding benzodiazepine in the rat in vivo. Rising, P. A.; Illing, H. P. A.; Johnson, P.; Yeomans, M. A. (Drug Dev., Hoechst Pharm. Res. Lab., Milton Keynes, Engl.). Xenobiotica, 7(7), 425-37 (English) 1977. CODEN: XENOBH. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) C 720045 (I) [59049-59-1] (10 mg/kg, orally) administered to rats was well absorbed and extensively metabolized; urinary thin layer chromatog. metabolite profiles after administration of labeled I, nimetazepam (II) [2011-67-8] or a substituted aminoacetamidobenzophenone were qual. similar but differed quant. Thin layer chromatog. of plasma exts. after I treatment showed that II and nitrazepam (III) [146-22-5] accounted for 20% of the total radioactivity and had a combined concn. 22 times greater than that of I. I was rapidly metabolized to polar metabolites in the liver and in the brain, the major metabolites were II and III. I was cyclized to II which was further metabolized to III.