Detail of "201165-99-3"
- CAS Number:
- 201165-99-3
- Name:
Thymidine, 2,3-didehydro-3-deoxy-5-O-(8-methoxy-2-oxido-4H-1,3,2-benzodioxaphosphorin-2-yl)-
- Molecular Structure:
- Formula:
- C18H19N2O8P
- Molecular Weight:
- 422.3258
- Density:
- 1.5g/cm3
- Boiling Point:
- °Cat760mmHg
- Flash Point:
- °C
Thymidine, 2,3-didehydro-3-deoxy-5-O-(8-methoxy-2-oxido-4H-1,3,2-benzodioxaphosphorin-2-yl)-
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Reference
- Cyclo-saligenyl-5-fluoro-2'-deoxyuridinemonophosphate (cycloSal-FDUMP) - a new prodrug approach for FDUMP
- Cyclo-saligenyl-5-fluoro-2'-deoxyuridinemonophosphate (cycloSal-FDUMP) - a new prodrug approach for FDUMP. Lorey, Martina; Meier, Chris; De Clercq, Eric; Balzarini, Jan (Institute of Organic Chemistry, Johann Wolfgang Goethe-University, Frankfurt am Main D-60439, Germany). Nucleosides & Nucleotides, 16(7-9), 1307-1310 (English) 1997 Marcel Dekker, Inc. CODEN: NUNUD5.Except for chemicals metioned above, 201165-99-3 is also used. ISSN: 0732-8311. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The synthesis of cycloSal-FdUMP derivs. as a new prodrug approach for 5-fluorouracil is described. The phosphotriesters release the FdUMP selectively by a controlled, chem. induced tandem reaction in hydrolysis studies. The biol. activity (IC50) of cycloSal-phosphotriesters was evaluated in FM3A/O cells and FM3A/TK- cells. .