Detail of "20168-99-4"

CAS Number:
20168-99-4
Name:
1H-Indole-3-aceticacid, 5-methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propen-1-yl)-
Molecular Structure:
Formula:
C21H19 N O4
Molecular Weight:
349.39
Synonyms:
1H-Indole-3-aceticacid, 5-methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propenyl)- (9CI); Indole-3-aceticacid, 1-cinnamoyl-5-methoxy-2-methyl- (8CI);1-Cinnamoyl-2-methyl-5-methoxyindolyl-3-acetic acid;1-Cinnamoyl-5-methoxy-2-methylindole-3-acetic acid; Cindomet; Cinmetacin;Cinmethacin; Indolacin
Density:
1.19g/cm³
Boiling Point:
488°Cat760mmHg
Flash Point:
248.9°C
Safety:
Poison by intraperitoneal route. Moderately toxic by ingestion. An anti-inflammatory agent. When heated to decomposition it emits toxic fumes of NO_x. Details

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Kinetics and mechanism of the basic hydrolysis of indomethacin and related compounds: a reevaluation: Kinetics and mechanism of the basic hydrolysis of indomethacin and related compounds: a reevaluation. Cipiciani, Antonio; Ebert, Cynthia; Linda, Paolo; Rubessa, Fulvio; Savelli, Gianfranco (Dip. Chim., Univ. Perugia, Perugia, Italy). J. Pharm. Sci., 72(9), 1075-6 (English) 1983. CODEN: JPMSAE. ISSN: 0022-3549. DOCUMENT TYPE: Journal CA Section: 22 (Physical Organic Chemistry) In the hydrolysis of indomethacin and related compds. in an alk. 27076-50-2 and 20168-99-4 which are cas registry numbers of substances are two of reagents here. medium at 25°, the kinetics showed a second-order rate dependence at low concns. of HO- and a first-order rate dependence at higher concns. of HO-. .

On the binding of cinmetacin and indomethacin to human serum albumin: On the binding of cinmetacin and indomethacin to human serum albumin. Montero, M. T.; Pouplana, R.; Valls, O.; Garcia, S. (Fac. Farm. 20168-99-4 and 53-86-1 are cas registry numbers. These chemicals are also mentioned in this article., Univ. Barcelona, Barcelona 08028, Spain). J. Pharm. Pharmacol., 38(12), 925-7 (English) 1986. CODEN: JPPMAB. ISSN: 0022-3573. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The binding of 2 nonsteroidal anti-inflammatory drugs, indomethacin [53-86-1] and cinmetacin [20168-99-4], to human serum albumin was studied by dynamic dialysis at 37° and pH 7.4. Cinmetacin is bound more than indomethacin. The affinity const. for the primary binding site is 4.28 ′ 106 M-1 for cinmetacin and 1.4 ′ 106 M-1 for indomethacin. The protein binding of indomethacin is decreased in the presence of cinmetacin. .