Reference

Antiviral 2,5-piperazinediones

Antiviral 2,5-piperazinediones. Vanzura, Jiri; Palat, Karel; Celadnik, Milan; Klimes, Jiri; Smejkal, Frantisek (Czech. ). Czech. CS 210383 B 15 Jul 1983,5 pp. (Czech). (Czechoslovakia). CODEN: CZXXA9. CLASS: IC: A61K031-495. ICA: C07D241-08.Several substances like 15136-27-3 may be metioned in this study. APPLICATION: CS 79-4491 28 Jun 1979. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacology) Section cross-reference(s): 28, 34 Numerous I (R = alkyl, aralkyl, aryl; R1 = alkyl, hydroxyalkyl, aralkyl, aryl; R2 and R3 = H or alkyl; or RR2 = methylene chain) were prepd. and tested for virustatic activity in mice. Thus, Z-Leu [2018-66-8] was coupled with Ala-OMe-HCl [2491-20-5] in the presence of N,N-dicyclohexylcarbodiimide and the resulting Z-Leu-Ala-OMe [43189-51-1] was deblocked with a soln. of HBr in AcOH or by hydrogenolysis, and cyclized with NH3 in dry MeOH to yield cyclo(L-Ala-L-Leu) [3-methyl-6-(2-methylpropyl)-2,5-piperazinedione] [24676-83-3]. I inhibited in vitro plaque formation in tissue cultures of chicken fibroblasts and had virustatic activity in mice infected with vaccinia virus. .

Kinetics of peptide condensation in aqueous-organic solvent: progressive inactivation and catalytic reaction

Kinetics of peptide condensation in aqueous-organic solvent: progressive inactivation and catalytic reaction.Some chemicals with cas registry numbers like 1161-13-3 and 2018-66-8 are also used. Kunugi, Shigeru; Yoshida, Masumi (Laboratory for Biopolymer Physics, Department of Polymer Science and Engineering, Kyoto Institute of Technology, Kyoto 606, Japan). Annals of the New York Academy of Sciences, 799(Enzyme Engineering XIII), 281-283 (English) 1996 New York Academy of Sciences. CODEN: ANYAA9. ISSN: 0077-8923. DOCUMENT TYPE: Journal CA Section: 34 (Amino Acids, Peptides, and Proteins) Section cross-reference(s): 9, 22 The effect of solvent on the kinetics of enzyme-catalyzed condensation of Cbz-Leu-OH or Cbz-Phe-OH (Cbz = benzyloxycarbonyl) with glycinamide was studied. The rate profiles take into account solvent-induced deactivation of the enzyme (thermolysin or carboxypeptidase Y). .