Detail of "2024-83-1"

Reference

Disposition of dobutamine in the dog

Disposition of dobutamine in the dog. Murphy, Patrick J.; Williams, Terry L.Several substances are used for example 2024-83-1 and 93-40-3 which are their cas registry numbers.; Kau, Donald L. K. (Lilly Res. Lab., Eli Lilly and Co., Indianapolis, Indiana, USA). J. Pharmacol. Exp. Ther., 199(2), 423-31 (English) 1976. CODEN: JPETAB. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The disposition of dobutamine-HCl (I) [52663-81-7], a potent inotropic catecholamine, was examd. in the dog. A sensitive assay was developed for I allowing the measurement of the drug at plasma concns. as low as 1 ng/ml. The short plasma half-life of I (1-2 min) was found to be due to rapid redistribution of I from the plasma to the tissue. When 14C-I was administered, the plasma half-life of radioactivity was 1.9 hr. The circulating radioactivity consists mainly of the glucuronide conjugate of 3-O-methyldobutamine. During continuous intravenous administration of I, plasma levels of metabolites reached a max. between 3 and 4 hr. During a 48-hr time period after administration of 14C-I, 67% of the radiolabel was excreted in the urine and 20% in the feces. In dogs having cannulated bile ducts, 30 to 35% of the administered drug was excreted in the bile. The major urinary metabolites were the glucuronide conjugates of I and 3-O-methyldobutamine. .

O-methylation effect on the carbon-13 nuclear magnetic resonance signals of ortho-substituted phenols

O-methylation effect on the carbon-13 nuclear magnetic resonance signals of ortho-substituted phenols. II. Fujita, Masao; Inoue, Takao; Nagai, Masahiro (Fac. Pharm. Sci., Hoshi Univ., Tokyo 142, Japan). Yakugaku Zasshi, 105(3), 240-8 (Japanese) 1985. CODEN: YKKZAJ. ISSN: 0031-6903. DOCUMENT TYPE: Journal CA Section: 22 (Physical Organic Chemistry) O-Methylation effects on chem. shifts (in DMSO-d6) of o-, p-disubstituted phenols were investigated. In o-substituted phenols with another substituent conjugated to the benzene ring at the para position, O-methylation caused downfield shifts of 1.1, 1.0 and 0. 2024-83-1 which is the cas registry number is also used here.8 ppm for ipso-C (C-1), substituted ortho-C (C-2) and para-C (C-4), resp., and upfield shifts of 1.1, 0.6 and 4.5 ppm for meta-C's (C-3 and C-5) and ortho methine C (C-6) resp. The trend of O-methylation effects on ipso-C (a smaller downfield shift) and meta-C's (larger upfield shifts) was different from that reported on o-substituted phenols with a proton or a nonconjugated substituent at the para position; however this trend was obsd. also on O-methylation of p-monosubstituted phenols. The regularity of a downfield shift of ~1.0 ppm for substituted ortho-C and an upfield shift of ~4.1-4.5 ppm for ortho-methine C was found not only on O-methylation of o-monosubstituted phenols, but also on that of o-substituted phenols with other substituents at meta and/or para positions. The above results were successfully applied to the 13C-NMR spectral interpretation of some natural products including coumarins and flavonoids. .